Alzheimer's disease (AD) is the most common neurodegenerative disease, with
characteristic extracellular amyloid-β (Aβ) deposition and intracellular accumulation of …

Alzheimer's disease (AD) predominantly occurs as a late onset (LOAD) form involving
neurodegeneration and cognitive decline with progressive memory loss. Risk factors that …

Pathological hallmarks of Alzheimer's disease (AD) precede clinical symptoms by years,
indicating a period of cognitive resilience before the onset of dementia. Here, we report that …

The gene-regulatory landscape of the brain is highly dynamic in health and disease,
coordinating a menagerie of biological processes across distinct cell types. Here, we …

Microglia, the innate immune cells of the brain, influence Alzheimer's disease (AD)
progression and are potential therapeutic targets. However, microglia exhibit diverse …

In addition to tau and Aβ pathologies, inflammation plays an important role in Alzheimer's
disease (AD). Variants in APOE and TREM2 increase AD risk. ApoE4 exacerbates tau …

Microglia are central players in brain innate immunity and have been the subject of
extensive research in Alzheimer's disease (AD). In this review, we aim to summarize the …

C9orf72 repeat expansions cause inherited amyotrophic lateral sclerosis
(ALS)/frontotemporal dementia (FTD) and result in both loss of C9orf72 protein expression …

Cell-based therapies are being developed for various neurodegenerative diseases that
affect the central nervous system (CNS). Concomitantly, the roles of individual cell types in …

The microtubule-associated protein tau aggregates in multiple neurodegenerative diseases,
causing inflammation and changing the inflammatory signature of microglia by unknown …