Following their exit from the thymus, T cells are endowed with potent effector functions but
must spare host tissue from harm. The fate of these cells is dictated by a series of …

This article reviews the development of the immune response through neonatal, infant and
adult life, including pregnancy, ending with the decline in old age. A picture emerges of a …

Epigenetic “clocks” can now surpass chronological age in accuracy for estimating biological
age. Here, we use four such age estimators to show that epigenetic aging can be reversed …

The human immune system is highly variable between individuals but relatively stable over
time within a given person. Recent conceptual and technological advances have enabled …

The thymus is the primary immune organ responsible for generating self‐tolerant and
immunocompetent T cells. However, the thymus gradually involutes during early life …

In the older adult, the benefits of vaccination to prevent infectious disease are limited, mainly
because of the adaptive immune system's inability to generate protective immunity. The age …

ABSTRACT Coronavirus disease 2019 (COVID-19) is an emerging disease that has
reached pandemic status by rapidly spreading worldwide. Elderly individuals and patients …

The impact of intrinsic aging upon human peripheral blood T cell subsets remains
incompletely quantified and understood. This impact must be distinguished from the …

The accumulation of CD28− T cells, particularly within the CD8 subset, is one of the most
prominent changes during T-cell homeostasis and function associated with aging in …

Ageing is characterised by cellular senescence, leading to imbalanced tissue maintenance,
cell death and compromised organ function. This is first observed in the thymus, the primary …