Much of the mammalian genome is transcribed, generating long non-coding RNAs
(lncRNAs) that can undergo post-transcriptional surveillance whereby only a subset of the …

The RNA exosome is a highly conserved ribonuclease endowed with 3′–5′ exonuclease
and endonuclease activities. The multisubunit complex resides in both the nucleus and the …

Newly made mRNAs are processed and packaged into mature ribonucleoprotein complexes
(mRNPs) and are recognized by the essential transcription–export complex (TREX) for …

The core components of the nuclear RNA export pathway are thought to be required for
export of virtually all polyadenylated RNAs. Here, we depleted different proteins that act in …

RNA concentration homeostasis involves coordinating RNA abundance and synthesis rates
with cell size. Here, we study this in human cells by combining genome-wide perturbations …

The RNA-binding ARS2 protein is centrally involved in both early RNA polymerase II
(RNAPII) transcription termination and transcript decay. Despite its essential nature, the …

Many active genes reproducibly position near nuclear speckles, but the functional
significance of this positioning is unknown. Here we show that HSPA1B BAC transgenes …

Summary N 6-Methyladenosine (m 6 A) on mRNAs mediates different biological processes
and its dysregulation contributes to tumorigenesis. How m 6 A dictates its diverse molecular …

The RNA-binding protein ALYREF (THOC4) is involved in transcriptional regulation and
nuclear mRNA export, though its role and molecular mode of action in breast carcinogenesis …

RNA surveillance pathways detect and degrade defective transcripts to ensure RNA fidelity.
We found that disrupted nuclear RNA surveillance is oncogenic. Cyclin-dependent kinase …