Critical care, like many healthcare areas, is under a dual assault from significantly
increasing demographic and economic pressures. Intensive care unit (ICU) patients are …

Since the early days of the Journal of Controlled Release, there has been considerable
interest in materials that can release drug on an “on-demand” basis. So called “stimuli …

Intensive insulin therapy (IIT) and tight glycaemic control (TGC), particularly in intensive care
unit (ICU), are the subjects of increasing and controversial debate in recent years. Model …

Introduction Stress-induced hyperglycaemia is prevalent in critical care. Control of blood
glucose levels to within a 4.4 to 6.1 mmol/L range or below 7.75 mmol/L can reduce mortality …

Targeted, tight model-based glycemic control in critical care patients that can reduce
mortality 18–45% is enabled by prediction of insulin sensitivity, SI. However, this parameter …

Tight glycemic control (TGC) has emerged as a major research focus in critical care due to
its potential to simultaneously reduce both mortality and costs. However, repeating initial …

Background In-silico virtual patients and trials offer significant advantages in cost, time and
safety for designing effective tight glycemic control (TGC) protocols. However, no such …

Background: Elevated blood glucose (BG) concentrations (Hyperglycaemia) are a common
complication in critically ill patients. Insulin therapy is commonly used to treat …

Intensive care unit (ICU) blood glucose control algorithms were reviewed and analyzed in
the context of linear systems theory and classical feedback control algorithms. Closed-loop …

Background Effective tight glycemic control (TGC) can improve outcomes in critical care
patients, but it is difficult to achieve consistently. Insulin sensitivity defines the metabolic …