Fruits, vegetables, spices, and herbs are a potential source of phenolic acids and
polyphenols. These compounds are known as natural by-products or secondary metabolites …

Introduction: Coronaviruses encode a helicase that is essential for viral replication and
represents an excellent antiviral target. However, only a few coronavirus helicase inhibitors …

Background Contemporary antiretroviral therapies (ART) and management strategies have
diminished both human immunodeficiency virus (HIV) treatment failure and the acquired …

Purpose The Swedish InfCareHIV cohort was established in 2003 to ensure equal and
effective care of people living with HIV (PLHIV) and enable long-term follow-up. InfCareHIV …

Abstract NeuroAIDS (Neuro Acquired Immunodeficiency Syndrome) or HIV (Human
Immunodeficiency Virus) associated neuronal abnormality is continuing to be a significant …

Objective: To determine the antiretroviral activity of the integrase strand transfer inhibitors
(INSTIs), raltegravir (RAL), elvitegravir (EVG), dolutegravir (DTG), cabotegravir (CAB) and …

HIV-Integrase (IN) has proven to be a viable target for highly specific HIV-1 therapy. We
aimed to characterize the HIV-1 IN gene in a South African context and identify resistance …

Resistance associated mutations (RAMs) threaten the long-term success of combination
antiretroviral therapy (cART) outcomes for HIV-1 treatment. HIV-1 Integrase (IN) strand …

Introduction: The HIV Prevention Trials Network (HPTN) 052 trial demonstrated that early
antiretroviral therapy (ART) prevented 93% of HIV transmission events in serodiscordant …

Human immunodeficiency virus type 1 (HIV-1) integrase (IN) integrates viral DNA into the
host genome using its 3′-end processing and strand-transfer activities. Due to the …