Classically considered short-lived and purely defensive leukocytes, neutrophils are unique
in their fast and moldable response to stimulation. This plastic behavior may underlie …

Macrophage-mediated inflammation is critical in the pathogenesis of non-alcoholic
steatohepatitis (NASH). Here, we describe that, with high-fat, high-sucrose-diet feeding …

Liver regeneration is a complex process involving the crosstalk of multiple cell types,
including hepatocytes, hepatic stellate cells, endothelial cells and inflammatory cells. The …

The gut and the liver are characterized by mutual interactions between both organs, the
microbiome, diet and other environmental factors. The sum of these interactions is …

Resident tissue macrophages (RTMs) have a broad spectrum of immune-and non-immune-
related tissue-supporting activities. The roots of this heterogeneity and versatility are only …

Tissue macrophages are immune cells whose phenotypes and functions are dictated by
origin and niches. However, tissues are complex environments, and macrophage …

Effective delivery of therapeutic and diagnostic nanoparticles is dependent on their ability to
accumulate in diseased tissues. However, most nanoparticles end up in liver macrophages …

Background & Aims Previous single-cell RNA-sequencing analyses have shown that Trem2-
expressing macrophages are present in the liver during obesity, non-alcoholic …

Tissue-resident and recruited macrophages contribute to both host defense and pathology.
Multiple macrophage phenotypes are represented in diseased tissues, but we lack deep …

Various lung insults can result in replacement of resident alveolar macrophages (AM) by
bone marrow monocyte–derived (BMo)–AM. However, the dynamics of this process and its …