The hepatocyte clock and feeding control chronophysiology of multiple liver cell types
Most cells of the body contain molecular clocks, but the requirement of peripheral clocks for
rhythmicity and their effects on physiology are not well understood. We show that deletion of …
rhythmicity and their effects on physiology are not well understood. We show that deletion of …
Dynamic Multiplex tissue imaging in inflammation research
S Uderhardt, G Neag… - Annual Review of …, 2024 - annualreviews.org
Inflammation is a highly dynamic process with immune cells that continuously interact with
each other and parenchymal components as they migrate through tissue. The dynamic …
each other and parenchymal components as they migrate through tissue. The dynamic …
Origins and diversity of macrophages in health and disease
Macrophages are the first immune cells in the developing embryo and have a central role in
organ development, homeostasis, immunity and repair. Over the last century, our …
organ development, homeostasis, immunity and repair. Over the last century, our …
BMP9 and BMP10: Two close vascular quiescence partners that stand out
A Desroches‐Castan, E Tillet… - Developmental …, 2022 - Wiley Online Library
Bone morphogenetic proteins (BMPs) are dimeric transforming growth factor ß (TGFß) family
cytokines that were first described in bone and cartilage formation but have since been …
cytokines that were first described in bone and cartilage formation but have since been …
Hemolysis dictates monocyte differentiation via two distinct pathways in sickle cell disease vaso-occlusion
Sickle cell disease (SCD) is a hereditary hemoglobinopathy characterized by painful vaso-
occlusive crises (VOC) and chronic hemolysis. The mononuclear phagocyte system is …
occlusive crises (VOC) and chronic hemolysis. The mononuclear phagocyte system is …
Cell death in hepatocellular carcinoma: pathogenesis and therapeutic opportunities
E García-Pras, A Fernández-Iglesias, J Gracia-Sancho… - Cancers, 2021 - mdpi.com
Simple Summary The progression of liver tumors is highly influenced by the interactions
between cancer cells and the surrounding environment, and, consequently, can determine …
between cancer cells and the surrounding environment, and, consequently, can determine …
[HTML][HTML] Hepatic stellate cells: dictating outcome in nonalcoholic fatty liver disease
L Wiering, P Subramanian, L Hammerich - Cellular and Molecular …, 2023 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) is a fast growing, chronic liver disease affecting∼
25% of the global population. Nonalcoholic fatty liver disease severity ranges from the less …
25% of the global population. Nonalcoholic fatty liver disease severity ranges from the less …
Delivery of mRNA for regulating functions of immune cells
Abnormal immune cell functions are commonly related to various diseases, including
cancer, autoimmune diseases, and infectious diseases. Messenger RNA (mRNA)-based …
cancer, autoimmune diseases, and infectious diseases. Messenger RNA (mRNA)-based …
Inflammation response after the cessation of chronic arsenic exposure and post-treatment of natural astaxanthin in liver: potential role of cytokine-mediated cell–cell …
Z Zhang, C Guo, H Jiang, B Han, X Wang, S Li, Y Lv… - Food & Function, 2020 - pubs.rsc.org
Ongoing groundwater arsenic contamination throughout China was first recognized in the
1960s. Groundwater arsenic contamination is a high risk for human and animal health …
1960s. Groundwater arsenic contamination is a high risk for human and animal health …
[HTML][HTML] Transcriptional space-time mapping identifies concerted immune and stromal cell patterns and gene programs in wound healing and cancer
Tissue repair responses in metazoans are highly coordinated by different cell types over
space and time. However, comprehensive single-cell-based characterization covering this …
space and time. However, comprehensive single-cell-based characterization covering this …