Invariant natural killer T cells: an innate activation scheme linked to diverse effector functions
PJ Brennan, M Brigl, MB Brenner - Nature Reviews Immunology, 2013 - nature.com
Invariant natural killer T (iNKT) cells exist in a'poised effector'state, which enables them to
rapidly produce cytokines following activation. Using a nearly monospecific T cell receptor …
rapidly produce cytokines following activation. Using a nearly monospecific T cell receptor …
The thick waxy coat of mycobacteria, a protective layer against antibiotics and the host's immune system
SM Batt, DE Minnikin, GS Besra - Biochemical Journal, 2020 - portlandpress.com
Tuberculosis, caused by the pathogenic bacterium Mycobacterium tuberculosis (Mtb), is the
leading cause of death from an infectious disease, with a mortality rate of over a million …
leading cause of death from an infectious disease, with a mortality rate of over a million …
The complexity of cardiolipin in health and disease
SM Claypool, CM Koehler - Trends in biochemical sciences, 2012 - cell.com
Cardiolipin, the signature phospholipid of mitochondria, is a lipid dimer that is important for a
diverse range of mitochondrial activities beyond the process of ATP production. Thus not …
diverse range of mitochondrial activities beyond the process of ATP production. Thus not …
Biology of CD1-and MR1-restricted T cells
M Salio, JD Silk, E Yvonne Jones… - Annual review of …, 2014 - annualreviews.org
Over the past 15 years, investigators have shown that T lymphocytes can recognize not only
peptides in the context of MHC class I and class II molecules but also foreign and self-lipids …
peptides in the context of MHC class I and class II molecules but also foreign and self-lipids …
Invariant natural killer T cells recognize lipid self antigen induced by microbial danger signals
Invariant natural killer T cells (i NKT cells) have a prominent role during infection and other
inflammatory processes, and these cells can be activated through their T cell antigen …
inflammatory processes, and these cells can be activated through their T cell antigen …
Hepatitis B virus–induced lipid alterations contribute to natural killer T cell–dependent protective immunity
S Zeissig, K Murata, L Sweet, J Publicover, Z Hu… - Nature medicine, 2012 - nature.com
In most adult humans, hepatitis B is a self-limiting disease leading to life-long protective
immunity, which is the consequence of a robust adaptive immune response occurring weeks …
immunity, which is the consequence of a robust adaptive immune response occurring weeks …
Peroxisome-derived lipids are self antigens that stimulate invariant natural killer T cells in the thymus
F Facciotti, GS Ramanjaneyulu, M Lepore… - Nature …, 2012 - nature.com
The development and maturation of semi-invariant natural killer T cells (i NKT cells) rely on
the recognition of self antigens presented by CD1d restriction molecules in thymus. The …
the recognition of self antigens presented by CD1d restriction molecules in thymus. The …
The immunology of CD1-and MR1-restricted T cells
CD1-and MHC-related molecule-1 (MR1)-restricted T lymphocytes recognize nonpeptidic
antigens, such as lipids and small metabolites, and account for a major fraction of circulating …
antigens, such as lipids and small metabolites, and account for a major fraction of circulating …
[HTML][HTML] Recognition of lyso-phospholipids by human natural killer T lymphocytes
LM Fox, DG Cox, JL Lockridge, X Wang, X Chen… - PLoS …, 2009 - journals.plos.org
Natural killer T (NKT) cells are a subset of T lymphocytes with potent immunoregulatory
properties. Recognition of self-antigens presented by CD1d molecules is an important route …
properties. Recognition of self-antigens presented by CD1d molecules is an important route …
Type II NKT cells and their emerging role in health and disease
MV Dhodapkar, V Kumar - The Journal of Immunology, 2017 - journals.aai.org
NKT cells recognize lipid Ags presented by a class I MHC-like molecule CD1d, a member of
the CD1 family. Although most initial studies on NKT cells focused on a subset with semi …
the CD1 family. Although most initial studies on NKT cells focused on a subset with semi …