Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing

SC Cunnane, E Trushina, C Morland… - Nature reviews Drug …, 2020 - nature.com
The brain requires a continuous supply of energy in the form of ATP, most of which is
produced from glucose by oxidative phosphorylation in mitochondria, complemented by …

[HTML][HTML] Neurodegenerative diseases–is metabolic deficiency the root cause?

VR Muddapu, SAP Dharshini… - Frontiers in …, 2020 - frontiersin.org
Neurodegenerative diseases, including Alzheimer, Parkinson, Huntington, and amyotrophic
lateral sclerosis, are a prominent class of neurological diseases currently without a cure …

Effect of high‐caloric nutrition on survival in amyotrophic lateral sclerosis

AC Ludolph, J Dorst, J Dreyhaupt… - Annals of …, 2020 - Wiley Online Library
Objective Weight loss has been identified as a negative prognostic factor in amyotrophic
lateral sclerosis, but there is no evidence regarding whether a high‐caloric diet increases …

Hypermetabolism in ALS is associated with greater functional decline and shorter survival

FJ Steyn, ZA Ioannides, RPA Van Eijk… - Journal of Neurology …, 2018 - jnnp.bmj.com
Objective To determine the prevalence of hypermetabolism, relative to body composition, in
amyotrophic lateral sclerosis (ALS) and its relationship with clinical features of disease and …

[HTML][HTML] Energy metabolism in ALS: an underappreciated opportunity?

T Vandoorne, K De Bock, L Van Den Bosch - Acta neuropathologica, 2018 - Springer
Amyotrophic lateral sclerosis (ALS) is a relentlessly progressive and fatal
neurodegenerative disorder that primarily affects motor neurons. Despite our increased …

[HTML][HTML] Role of brain liver X receptor in Parkinson's disease: hidden treasure and emerging opportunities

SA Alnaaim, HM Al-Kuraishy, A Alexiou… - Molecular …, 2024 - Springer
Parkinson's disease (PD) is a neurodegenerative disease due to the degeneration of
dopaminergic neurons (DNs) in the substantia nigra (SN). The liver X receptor (LXR) is …

[HTML][HTML] Hypothalamic alterations in neurodegenerative diseases and their relation to abnormal energy metabolism

P Vercruysse, D Vieau, D Blum, Å Petersén… - Frontiers in molecular …, 2018 - frontiersin.org
Neurodegenerative diseases (NDDs) are disorders characterized by progressive
deterioration of brain structure and function. Selective neuronal populations are affected …

Hypothalamic atrophy is related to body mass index and age at onset in amyotrophic lateral sclerosis

M Gorges, P Vercruysse, HP Müller… - Journal of Neurology …, 2017 - jnnp.bmj.com
Objective Our objective was to study the hypothalamic volume in a cohort of patients with
amyotrophic lateral sclerosis (ALS) including symptomatic and presymptomatic ALS …

[HTML][HTML] Eating behavior in aging and dementia: the need for a comprehensive assessment

S Fostinelli, R De Amicis, A Leone, V Giustizieri… - Frontiers in …, 2020 - frontiersin.org
Eating behavior can change during aging due to physiological, psychological, and social
changes. Modifications can occur at different levels:(1) in food choice,(2) in eating habits …

[HTML][HTML] Transcranial magnetic stimulation for the assessment of neurodegenerative disease

S Vucic, MC Kiernan - Neurotherapeutics, 2017 - Elsevier
Transcranial magnetic stimulation (TMS) is a noninvasive technique that has provided
important information about cortical function across an array of neurodegenerative …