Targeting BRD4 with PROTAC degrader ameliorates LPS-induced acute lung injury by inhibiting M1 alveolar macrophage polarization

D Li, Y Deng, G Wen, L Wang, X Shi, S Chen… - International …, 2024 - Elsevier
Objectives Acute lung injury (ALI) is a highly inflammatory condition with the involvement of
M1 alveolar macrophages (AMs) polarization, eventually leading to the development of non …

[HTML][HTML] Folate-modified liposomes mediate the co-delivery of cisplatin with miR-219a-5p for the targeted treatment of cisplatin-resistant lung cancer

Y Wu, J Zhang, J Zhao, B Wang - BMC Pulmonary Medicine, 2024 - Springer
Cisplatin (DDP) resistance, often leading to first-line chemotherapy failure in non-small cell
lung cancer (NSCLC), poses a significant challenge. MiR-219a-5p has been reported to …

[HTML][HTML] m6A-dependent mature miR-151-5p accelerates the malignant process of HNSCC by targeting LYPD3

F Huang, Y Ren, Y Hua, Y Wang, R Li, N Ji, X Zeng… - Molecular …, 2024 - Springer
Abstract miRNA has emerged as a crucial regulator in various of pathological and
physiological processes, yet its precise mechanism of action the detailed mechanism of their …