Of mice and not men: differences between mouse and human immunology
J Mestas, CCW Hughes - The Journal of Immunology, 2004 - journals.aai.org
Mice are the experimental tool of choice for the majority of immunologists and the study of
their immune responses has yielded tremendous insight into the workings of the human …
their immune responses has yielded tremendous insight into the workings of the human …
Multiple roles for CD4+ T cells in anti‐tumor immune responses
R Kennedy, E Celis - Immunological reviews, 2008 - Wiley Online Library
Our understanding of the importance of CD4+ T cells in orchestrating immune responses
has grown dramatically over the past decade. This lymphocyte family consists of diverse …
has grown dramatically over the past decade. This lymphocyte family consists of diverse …
[HTML][HTML] Mesenchymal stromal cell exosome–enhanced regulatory T-cell production through an antigen-presenting cell–mediated pathway
Background aims The immunomodulatory property of mesenchymal stromal cell (MSC)
exosomes is well documented. On the basis of our previous report that MSC exosomes …
exosomes is well documented. On the basis of our previous report that MSC exosomes …
Function and regulation of MHC class II molecules in T-lymphocytes: of mice and men
TM Holling, E Schooten, PJ van Den Elsen - Human immunology, 2004 - Elsevier
The main function of major histocompatibility complex (MHC) class II molecules is to present
processed antigens, which are derived primarily from exogenous sources, to CD4+ T …
processed antigens, which are derived primarily from exogenous sources, to CD4+ T …
Human CD4+CD25+ cells: a naturally occurring population of regulatory T cells
Despite thymic deletion of cells with specificity for self-antigens, autoreactive T cells are
readily detectable in the normal T-cell repertoire. In recent years, a population of CD4+ T …
readily detectable in the normal T-cell repertoire. In recent years, a population of CD4+ T …
Angiogenesis-inflammation cross-talk: vascular endothelial growth factor is secreted by activated T cells and induces Th1 polarization
F Mor, FJ Quintana, IR Cohen - The Journal of Immunology, 2004 - journals.aai.org
Vascular endothelial growth factor (VEGF) and its receptors are critical in angiogenesis. The
main player in the secretion and response to VEGF is the endothelial cell. We initiated this …
main player in the secretion and response to VEGF is the endothelial cell. We initiated this …
CD4+ T cell-released exosomes inhibit CD8+ cytotoxic T-lymphocyte responses and antitumor immunity
T cells secrete bioactive exosomes (EXO), but the potential immunoregulatory effect of T-cell
EXO is largely unknown. In this study, we generated activated ovalbumin (OVA)-specific …
EXO is largely unknown. In this study, we generated activated ovalbumin (OVA)-specific …
The value of animal models for drug development in multiple sclerosis
The rodent model for multiple sclerosis, experimental allergic (autoimmune)
encephalomyelitis (EAE), has been used to dissect molecular mechanisms of the …
encephalomyelitis (EAE), has been used to dissect molecular mechanisms of the …
Dendritic cells recruit T cell exosomes via exosomal LFA-1 leading to inhibition of CD8+ CTL responses through downregulation of peptide/MHC class I and Fas …
Active T cells release bioactive exosomes (EXOs). However, its potential modulation in
immune responses is elusive. In this study, we in vitro generated active OVA-specific CD8+ …
immune responses is elusive. In this study, we in vitro generated active OVA-specific CD8+ …
Lymphocytes and trogocytosis-mediated signaling
Trogocytosis is the intercellular transfer of membrane and membrane-associated molecules.
This underappreciated process has been described in a variety of biological settings …
This underappreciated process has been described in a variety of biological settings …