Virus-like particles (VLPs) are multiprotein structures that mimic the organization and
conformation of authentic native viruses but lack the viral genome, potentially yielding safer …

In December 1983, a seminal paper appeared on the overexpression of human IFN-β in
insect cells with a genetically engineered baculovirus. The finding that baculoviruses …

Viral infectious diseases threaten human health and global stability. Several vaccine
platforms, such as DNA, mRNA, recombinant viral vectors, and virus-like particle-based …

ABSTRACT The MetaCyc database (MetaCyc. org) is a comprehensive and freely
accessible resource for metabolic pathways and enzymes from all domains of life. The …

Virus-like particles (VLPs) hold tremendous potential as vaccine candidates. These
innovative biopharmaceuticals present the remarkable advantages of closely mimicking the …

The baculovirus‐insect cell expression system is widely used in producing recombinant
proteins. This review is focused on the use of this expression system in developing …

One of the main challenges in the development of bioprocesses based on cell transient
expression is the commonly reported reduction of cell specific productivity at increasing cell …

Insect cells (IC) and particularly lepidopteran cells are an attractive alternative to mammalian
cells for biomanufacturing. Insect cell culture, coupled with the lytic expression capacity of …

Baculovirus infects insects in nature and is non-pathogenic to humans, but can transduce a
broad range of mammalian and avian cells. Thanks to the biosafety, large cloning capacity …

When a virus infects a host cell, it hijacks the biosynthetic capacity of the cell to produce
virus progeny, a process that may take less than an hour or more than a week. The overall …