Despite rapid progress in the field, scalable high‐yield production of adeno‐associated virus
(AAV) is still one of the critical bottlenecks the manufacturing sector is facing. The insect cell …

Although microarray and expressed sequence tag (EST)-based approaches have been
used to profile gene expression during baculovirus infection, the response of host genes to …

Virus-like particles (VLPs) are multiprotein structures that resemble the conformation of
native viruses but lack a viral genome, potentiating their application as safer and cheaper …

In recent years, the use of adeno‐associated viruses (AAVs) as vectors for gene and cell
therapy has increased, leading to a rise in the amount of AAV vectors required during pre …

Productive infection of Trichoplusia ni cells by the baculovirus Autographa californica
multiple nucleopolyhedrovirus (AcMNPV) leads to expression of∼ 156 viral genes and …

Bioreactors are widely used in cell culture-based viral vaccine production, especially during
the coronavirus disease 2019 (COVID-19) pandemic. In this context, the development and …

The hitherto unexplained reduction of cell-specific productivity in transient gene expression
(TGE) at high cell density (HCD) is known as the cell density effect (CDE). It currently …

Mammalian cell cultures are increasingly used for the production of complex
biopharmaceuticals including viral vectors and vaccines. HEK293 is the predominant cell …

The insect cells/baculovirus system is well recognized as a safe and suitable technology to
produce heterologous proteins, vaccines and vectors for gene therapy. Efficient and robust …

The production of virus-like particles (VLPs) has gained importance over the last few years
owing to the benefits they provide compared to conventional vaccines. The …