Recently, mitochondria have been identified as important contributors to the virulence and
drug tolerance of human fungal pathogens. In different scenarios, either hypo-or …

Metabolic processes occurring during host–microbiota–pathogen interactions can favorably
or negatively influence host survival during infection. Defining the metabolic needs of the …

The survival of all microbes depends upon their ability to respond to environmental
challenges. To establish infection, pathogens such as C andida albicans must mount …

To fight infections, macrophages undergo a metabolic shift whereby increased glycolysis
fuels antimicrobial inflammation and killing of pathogens. Here we demonstrate that the …

Cryptococcus neoformans causes life-threatening meningoencephalitis in humans, but its
overall biological and pathogenic regulatory circuits remain elusive, particularly due to the …

The major fungal pathogen C andida albicans can occupy diverse microenvironments in its
human host. During colonization of the gastrointestinal or urogenital tracts, mucosal …

Cryptococcus neoformans is a major human central nervous system (CNS) fungal pathogen
causing considerable morbidity and mortality. In this study, we provide the widest view to …

Fungal pathogens must assimilate local nutrients to establish an infection in their
mammalian host. We focus on carbon, nitrogen, and micronutrient assimilation mechanisms …

Cryptococcus neoformans causes fatal fungal meningoencephalitis. Here, we study the
roles played by fungal kinases and transcription factors (TFs) in blood-brain barrier (BBB) …

Nutrient sensing is critical for adaptation of fungi to environmental and host conditions. The
conserved cAMP/PKA signaling pathway contributes to adaptation by sensing the …