Phenotypic drug discovery: recent successes, lessons learned and new directions
F Vincent, A Nueda, J Lee, M Schenone… - Nature Reviews Drug …, 2022 - nature.com
Many drugs, or their antecedents, were discovered through observation of their effects on
normal or disease physiology. For the past generation, this phenotypic drug discovery …
normal or disease physiology. For the past generation, this phenotypic drug discovery …
[HTML][HTML] The horizon of bone organoid: A perspective on construction and application
Bone defects repair and regeneration by various causes such as tumor resection, trauma,
degeneration, etc. have always been a key issue in the clinics. As one of the few organs that …
degeneration, etc. have always been a key issue in the clinics. As one of the few organs that …
[HTML][HTML] Artificial intelligence in drug discovery: what is realistic, what are illusions? Part 1: Ways to make an impact, and why we are not there yet
A Bender, I Cortés-Ciriano - Drug discovery today, 2021 - Elsevier
Highlights•Artificial Intelligence (AI) has transformed many areas such as speech and image
recognition, but not yet drug discovery.•Approaches to AI in drug discovery need to take in …
recognition, but not yet drug discovery.•Approaches to AI in drug discovery need to take in …
[HTML][HTML] Generation of tumor-reactive T cells by co-culture of peripheral blood lymphocytes and tumor organoids
KK Dijkstra, CM Cattaneo, F Weeber, M Chalabi… - Cell, 2018 - cell.com
Cancer immunotherapies have shown substantial clinical activity for a subset of patients with
epithelial cancers. Still, technological platforms to study cancer T-cell interactions for …
epithelial cancers. Still, technological platforms to study cancer T-cell interactions for …
Kinase inhibitors: the road ahead
FM Ferguson, NS Gray - Nature reviews Drug discovery, 2018 - nature.com
Receptor tyrosine kinase signalling pathways have been successfully targeted to inhibit
proliferation and angiogenesis for cancer therapy. However, kinase deregulation has been …
proliferation and angiogenesis for cancer therapy. However, kinase deregulation has been …
Human cardiac organoids for the modelling of myocardial infarction and drug cardiotoxicity
DJ Richards, Y Li, CM Kerr, J Yao, GC Beeson… - Nature biomedical …, 2020 - nature.com
Environmental factors are the largest contributors to cardiovascular disease. Here we show
that cardiac organoids that incorporate an oxygen-diffusion gradient and that are stimulated …
that cardiac organoids that incorporate an oxygen-diffusion gradient and that are stimulated …
[HTML][HTML] Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability
Cancer cell metabolism is heavily influenced by microenvironmental factors, including
nutrient availability. Therefore, knowledge of microenvironmental nutrient levels is essential …
nutrient availability. Therefore, knowledge of microenvironmental nutrient levels is essential …
Biased signalling: from simple switches to allosteric microprocessors
G protein-coupled receptors (GPCRs) are the largest class of receptors in the human
genome and some of the most common drug targets. It is now well established that GPCRs …
genome and some of the most common drug targets. It is now well established that GPCRs …
[HTML][HTML] Opportunities and challenges in phenotypic drug discovery: an industry perspective
Phenotypic drug discovery (PDD) approaches do not rely on knowledge of the identity of a
specific drug target or a hypothesis about its role in disease, in contrast to the target-based …
specific drug target or a hypothesis about its role in disease, in contrast to the target-based …
Drug repurposing from the perspective of pharmaceutical companies
Drug repurposing holds the potential to bring medications with known safety profiles to new
patient populations. Numerous examples exist for the identification of new indications for …
patient populations. Numerous examples exist for the identification of new indications for …