Attributable to its late diagnosis, early metastasis, and poor prognosis, pancreatic cancer
remains one of the most lethal diseases worldwide. Unlike other solid tumors, pancreatic …

Metastasis is the main cause of cancer-related mortality. Although the actual process of
metastasis remains largely elusive, epithelial-mesenchymal transition (EMT) has been …

Novel effective treatment is direly needed for patients with pancreatic ductal
adenocarcinoma (PDAC). Therapeutics that target the driver mutations, especially the KRAS …

Trafficking of biological material across membranes is an evolutionary conserved
mechanism and is part of any normal cell homeostasis. Such transport is composed of …

The tumor microenvironment is a complex system, playing an important role in tumor
development and progression. Besides cellular stromal components, extracellular matrix …

Extracellular vesicles (EV) are lipid-bilayer enclosed vesicles in submicron size that are
released from cells. A variety of molecules, including proteins, DNA fragments, RNAs, lipids …

The contribution of long noncoding RNAs (lncRNAs) to pancreatic cancer progression and
the regulatory mechanisms of their expression are attractive areas. In the present study, the …

Elevation of the level of intracellular reactive oxygen species (ROS) has immense
implication in the biological system. On the one hand, ROS promote the signaling cascades …

Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal solid tumors with
an overall five-year survival rate of that has only just reached 10%. The tumor …

Efforts to improve the clinical management of several cancers include finding better methods
for the quantitative and qualitative analysis of circulating tumor cells (CTCs). However …