Sirtuins are the class III of histone deacetylases whose deacetylate of histones is dependent
on nicotinamide adenine dinucleotide (NAD+). Among seven sirtuins, SIRT1 plays a critical …

Abstract Sirtuin (Yeast Silent Information RegulatorsⅡ, Sir2) was first discovered in the
1970s. Because of its function by removing acetylated groups from histones in the presence …

Reducing infarct size during a cardiac ischaemic‐reperfusion episode is still of paramount
importance, because the extension of myocardial necrosis is an important risk factor for …

Background and Purpose Catalpol, a water‐soluble active ingredient isolated from
Rehmannia glutinosa, exhibits multiple pharmacological activities. However, the mechanism …

Inflammatory bowel disease (IBD), which includes ulcerative colitis (UC) and Crohn's
disease (CD), is a group of chronic and incurable inflammatory diseases involving the …

Abstract Sirtuins (SIRT1–7) are distinct histone deacetylases (HDACs) whose activity is
determined by cellular metabolic status andnicotinamide adenine dinucleotide (NAD+) …

Natural coumarins and their derivatives isolated from various plants or microorganisms have
inherent antioxidant, antibacterial, antifungal, antiviral and anticancer properties among …

The therapeutic potential of natural stilbenes, with a particular focus on pterostilbene (PTE),
has emerged as a promising avenue of research targeting age-associated conditions …

In recent years, sirtuins (SIRTs) gained an increasing consideration because of their multiple
key roles in several biological settings such as the regulation of transcription, energetic …

Systemic lupus erythematosus (SLE) is a potentially fatal multisystem inflammatory chronic
disorder, the etiology and pathogenesis of which remain unclear. The loss of immune …