Cancer stem cells—origins and biomarkers: perspectives for targeted personalized therapies

L Walcher, AK Kistenmacher, H Suo, R Kitte… - Frontiers in …, 2020 - frontiersin.org
The use of biomarkers in diagnosis, therapy and prognosis has gained increasing interest
over the last decades. In particular, the analysis of biomarkers in cancer patients within the …

Elucidating the mechanisms of Temozolomide resistance in gliomas and the strategies to overcome the resistance.

MS Tomar, A Kumar, C Srivastava… - Biochimica et Biophysica …, 2021 - Elsevier
Temozolomide (TMZ) is a first-choice alkylating agent inducted as a gold standard therapy
for glioblastoma multiforme (GBM) and astrocytoma. A majority of patients do not respond to …

Leveraging a disulfidptosis-based signature to improve the survival and drug sensitivity of bladder cancer patients

H Chen, W Yang, Y Li, L Ma, Z Ji - Frontiers in immunology, 2023 - frontiersin.org
Background Disulfidptosis is a recently discovered form of cell death. However, its biological
mechanisms in bladder cancer (BCa) are yet to be understood. Methods Disulfidptosis …

[HTML][HTML] Dysregulated FOXM1 signaling in the regulation of cancer stem cells

G Sher, T Masoodi, K Patil, S Akhtar… - Seminars in Cancer …, 2022 - Elsevier
Since the introduction of the cancer stem cell (CSC) paradigm, significant advances have
been made in understanding the functional and biological plasticity of these elusive …

Malignant ascites in ovarian cancer: cellular, acellular, and biophysical determinants of molecular characteristics and therapy response

BP Rickard, C Conrad, AJ Sorrin, MK Ruhi, JC Reader… - Cancers, 2021 - mdpi.com
Simple Summary Accumulation of excess fluid in the abdomen typically indicates abnormal
function or disease, such as cancer, in the underlying tissues. This accumulation of fluid, or …

[HTML][HTML] Role of OCT4 in cancer stem-like cells and chemotherapy resistance

IS Mohiuddin, SJ Wei, MH Kang - … Acta (BBA)-Molecular Basis of Disease, 2020 - Elsevier
Cancer stem-like cells (CSCs) contribute to the tumorigenicity, progression, and
chemoresistance of cancers. It is not known whether CSCs arise from normal stem cells or if …

Breast cancer stem cells: Features, key drivers and treatment options

J Dittmer - Seminars in cancer biology, 2018 - Elsevier
The current view is that breast cancer is a stem cell disease characterized by the existence
of cancer cells with stem-like features and tumor-initiating potential. These cells are made …

Curcumin suppresses lung cancer stem cells via inhibiting Wnt/β‐catenin and sonic hedgehog pathways

JY Zhu, X Yang, Y Chen, YE Jiang… - Phytotherapy …, 2017 - Wiley Online Library
Cancer stem cells (CSCs) are highly implicated in the progression of human cancers. Thus,
targeting CSCs may be a promising strategy for cancer therapy. Wnt/β‐catenin and Sonic …

Transcriptional factors targeting in cancer stem cells for tumor modulation

A Chaudhary, SS Raza, R Haque - Seminars in Cancer Biology, 2023 - Elsevier
Abstract Cancer Stem Cells (CSCs) are now considered the primary" seeds" for the onset,
development, metastasis, and recurrence of tumors. Despite therapeutic breakthroughs …

[HTML][HTML] Regulation of cancer stem cells in triple negative breast cancer

N Fultang, M Chakraborty… - Cancer Drug …, 2021 - ncbi.nlm.nih.gov
Abstract Triple Negative Breast Cancer (TNBC) is the most lethal subtype of breast cancer.
Despite the successes of emerging targeted therapies, relapse, recurrence, and therapy …