[HTML][HTML] Ketamine as a novel psychopharmacotherapy for eating disorders: Evidence and future directions
A Ragnhildstveit, M Slayton, LK Jackson, M Brendle… - Brain Sciences, 2022 - mdpi.com
Eating disorders (EDs) are serious, life-threatening psychiatric conditions associated with
physical and psychosocial impairment, as well as high morbidity and mortality. Given the …
physical and psychosocial impairment, as well as high morbidity and mortality. Given the …
Roles of the monoaminergic system in the antidepressant effects of ketamine and its metabolites
While the molecular target of (R, S)-ketamine (ketamine) is thought to be the NMDA receptor,
subanesthetic doses of ketamine have been known to modulate monoaminergic …
subanesthetic doses of ketamine have been known to modulate monoaminergic …
[HTML][HTML] Ketamine for treatment of mood disorders and suicidality: a narrative review of recent progress
BACKGROUND: Mood disorders are a leading cause of morbidity. Many patients
experience treatment-resistant depression (TRD), and suicide rates are rising. Faster-acting …
experience treatment-resistant depression (TRD), and suicide rates are rising. Faster-acting …
Esketamine: a glimmer of hope in treatment-resistant depression
The motive of this article is to review the pharmacological and clinical aspects of esketamine
(ESK), an NMDA-receptor antagonist approved recently by the FDA for treatment-resistant …
(ESK), an NMDA-receptor antagonist approved recently by the FDA for treatment-resistant …
[HTML][HTML] Efficacy and safety of intranasal esketamine in treatment-resistant depression in adults: a systematic review
A Sapkota, H Khurshid, IA Qureshi, N Jahan, TR Went… - Cureus, 2021 - ncbi.nlm.nih.gov
Intranasal form of esketamine, the S-enantiomer of racemic ketamine, was approved by the
US FDA in 2019 for treatment-resistant depression (TRD) in adults. Since intranasal …
US FDA in 2019 for treatment-resistant depression (TRD) in adults. Since intranasal …
[HTML][HTML] Neurological adverse events associated with esketamine: a disproportionality analysis for signal detection leveraging the FDA adverse event reporting system
H Guo, B Wang, S Yuan, S Wu, J Liu, M He… - Frontiers in …, 2022 - frontiersin.org
Esketamine was approved for the treatment of treatment-resistant depression in 2019. After
the approval of esketamine, numerous concerns have been raised regarding its long-term …
the approval of esketamine, numerous concerns have been raised regarding its long-term …
A new rapid-acting antidepressant
The discovery of the strikingly rapid and robust antidepressant effects of r/s-ketamine for the
treatment of antidepressant-resistant symptoms of depression has led to new insights into …
treatment of antidepressant-resistant symptoms of depression has led to new insights into …
Weapons of stress reduction:(R, S)-ketamine and its metabolites as prophylactics for the prevention of stress-induced psychiatric disorders
Exposure to stress is one of the greatest contributing factors to developing a psychiatric
disorder, particularly in susceptible populations. Enhancing resilience to stress could be a …
disorder, particularly in susceptible populations. Enhancing resilience to stress could be a …
Repeated (S)-ketamine administration ameliorates the spatial working memory impairment in mice with chronic pain: role of the gut microbiota–brain axis
Y Jiang, X Wang, J Chen, Y Zhang, K Hashimoto… - Gut …, 2024 - Taylor & Francis
Chronic pain is commonly linked with diminished working memory. This study explores the
impact of the anesthetic (S)-ketamine on spatial working memory in a chronic constriction …
impact of the anesthetic (S)-ketamine on spatial working memory in a chronic constriction …
DNA methylation and the opposing NMDAR dysfunction in schizophrenia and major depression disorders: a converging model for the therapeutic effects of …
Psychedelic compounds are being increasingly explored as a potential therapeutic option
for treating several psychiatric conditions, despite relatively little being known about their …
for treating several psychiatric conditions, despite relatively little being known about their …