Heavy metals exposure and Alzheimer's disease and related dementias

KM Bakulski, YA Seo, RC Hickman… - Journal of …, 2020 - content.iospress.com
Alzheimer's disease and related dementias lack effective treatment or cures and are major
public health challenges. Risk for Alzheimer's disease and related dementias is partially …

Manganese is essential for neuronal health

KJ Horning, SW Caito, KG Tipps… - Annual review of …, 2015 - annualreviews.org
The understanding of manganese (Mn) biology, in particular its cellular regulation and role
in neurological disease, is an area of expanding interest. Mn is an essential micronutrient …

The aging brain: Impact of heavy metal neurotoxicity

OM Ijomone, CW Ifenatuoha, OM Aluko… - Critical reviews in …, 2020 - Taylor & Francis
The aging process is accompanied by critical changes in cellular and molecular functions,
which upset the homeostatic balance in the central nervous system. Accumulation of metals …

Manganese-based advanced nanoparticles for biomedical applications: future opportunity and challenges

S Haque, S Tripathy, CR Patra - Nanoscale, 2021 - pubs.rsc.org
Nanotechnology is the most promising technology to evolve in the last decade. Recent
research has shown that transition metal nanoparticles especially manganese (Mn)-based …

[HTML][HTML] Functions of manganese in reproduction

JM Studer, WP Schweer, NK Gabler… - Animal Reproduction …, 2022 - Elsevier
Manganese (Mn) is the twelfth most abundant element in the earth's crust and is widely
distributed throughout the surface of the planet, naturally occurring in rocks, soil, water, and …

SLC39A14 deficiency alters manganese homeostasis and excretion resulting in brain manganese accumulation and motor deficits in mice

S Jenkitkasemwong, A Akinyode… - Proceedings of the …, 2018 - National Acad Sciences
Solute carrier family 39, member 14 (SLC39A14) is a transmembrane transporter that can
mediate the cellular uptake of zinc, iron, and manganese (Mn). Studies of Slc39a14 …

Mechanisms of gene-environment interactions in Parkinson's disease

SM Fleming - Current environmental health reports, 2017 - Springer
Abstract Purpose of Review The purpose of the study was to discuss the main mechanisms
associated with environmental and genetic factors that contribute to the development of …

Manganese (II) chloride alters behavioral and neurochemical parameters in larvae and adult zebrafish

S Altenhofen, MT Wiprich, LR Nery, CE Leite… - Aquatic Toxicology, 2017 - Elsevier
Manganese (Mn) is an essential metal for organisms, but high levels can cause serious
neurological damage. The aim of this study was to evaluate the effects of MnCl 2 exposure …

Vitamin E protects dopaminergic neurons against manganese-induced neurotoxicity through stimulation of CHRM1 and KCNJ4

R Song, H Chen, R Zhan, M Han, L Zhao… - Journal of Trace Elements …, 2024 - Elsevier
Abstract Background Manganese (Mn) overexposure can induce neurotoxicity and lead to
manganism. Vitamin E (Vit E) has neuroprotective effects by acting as an ROS scavenger …

[HTML][HTML] The cGAS-STING-mediated NLRP3 inflammasome is involved in the neurotoxicity induced by manganese exposure

J Liu, X Zhang, H Wang - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Heavy metal pollution has become a global health challenge. Exposure to heavy metals
represents a major health risk. Manganese (Mn) is an essential trace element but also an …