Several promising strategies based on combining or cycling different antibiotics have been
proposed to increase efficacy and counteract resistance evolution, but we still lack a deep …

Networks of molecular regulators are often the primary objects of focus in the study of gene
regulation, with the machinery of protein synthesis tacitly relegated to the background …

Microbial communities are composed of cells of varying metabolic capacity, and regularly
include auxotrophs that lack essential metabolic pathways. Through analysis of auxotrophs …

Epistasis occurs when the effect of a mutation depends on its carrier's genetic background.
Despite increasing evidence that epistasis for fitness is common, its role during evolution is …

Antibiotic resistance is currently one of the most important public health problems. The
golden age of antibiotic discovery ended decades ago, and new approaches are urgently …

Background Horizontal gene transfer (HGT) plays a critical role in the spread of antibiotic
resistance and the evolutionary shaping of bacterial communities. Conjugation is the most …

Missense driver mutations in cancer are concentrated in a few hotspots. Various
mechanisms have been proposed to explain this skew, including biased mutational …

Control interventions steer the evolution of molecules, viruses, microorganisms or other cells
towards a desired outcome. Applications range from engineering biomolecules and …

The emergence of antimicrobial resistance (AMR) in bacterial pathogens represents a
global health threat. The metabolic state of bacteria is associated with a range of genetic …

The unbinding pathway of a protein complex can vary significantly depending on
biochemical and mechanical factors. Under mechanical stress, a complex may dissociate …