In their extensive 18-author review of the state-of-the-art of GP map research, Susanna
Manrubia et al.[1] address the" problem of the genotype-phenotype (GP) map", which is …

The emergence of antimicrobial resistance (AMR) in bacterial pathogens represents a
global health threat. The metabolic state of bacteria is associated with a range of genetic …

The series of comments [1–4] on our review on the map between genotypes, phenotypes,
and eventually organisms [5] are gratifying in that they are exactly the discussion we hoped …

All organisms construct the shared environment in which they live. This is especially notable
in micro-organisms as they secrete and uptake a diverse range of metabolites depending on …

Predicting the dynamics of mutation spread in engineered cell populations is a sought-after
goal in synthetic biology. Until now, models that capture these processes have been lacking …

Neisseria gonorrhoeae, the causative agent of the human disease gonorrhea, has a
substantial global burden of disease, causing more than 100 million cases a year …

It has been debated for decades whether gene-by-gene interactions (G× G or epistasis)
influence evolutionary processes (reviewed in [1, 2]). Compelling evidence for the …

C3 Photosynthetic Carbon Metabolism: The Maximization of CO2 Uptake and the
Minimization of the Total Protein-Nitrogen Concentration Multi-objective Optimization for …

Evolution is short-sighted; as a population adapts, natural selection can only act on existing
genetic variation, a key tenet of Darwinian evolutionary theory. For asexually evolving …

Besides genetic mutations, the metabolic state of bacterial cells represents another driving
factor in the emergence of antimicrobial resistance and in the actual efficacy of treatments. In …