Alzheimer's disease and its treatment by different approaches: A review

S Srivastava, R Ahmad, SK Khare - European Journal of Medicinal …, 2021 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disorder that impairs mental ability
development and interrupts neurocognitive function. This neuropathological condition is …

[HTML][HTML] New insights into the complex role of mitochondria in Parkinson's disease

A Grünewald, KR Kumar, CM Sue - Progress in neurobiology, 2019 - Elsevier
New discoveries providing insights into mitochondrial bioenergetics, their dynamic
interactions as well as their role in cellular homeostasis have dramatically advanced our …

[HTML][HTML] Mitochondria as potential targets in Alzheimer disease therapy: an update

G Cenini, W Voos - Frontiers in pharmacology, 2019 - frontiersin.org
Alzheimer disease (AD) is a progressive and deleterious neurodegenerative disorder that
affects mostly the elderly population. At the moment, no effective treatments are available in …

[HTML][HTML] Mitochondrial-derived vesicles compensate for loss of LC3-mediated mitophagy

CG Towers, DK Wodetzki, J Thorburn, KR Smith… - Developmental cell, 2021 - cell.com
Mitochondria are critical metabolic and signaling hubs, and dysregulated mitochondrial
homeostasis is implicated in many diseases. Degradation of damaged mitochondria by …

Apoptosis and its therapeutic implications in neurodegenerative diseases

NS Erekat - Clinical Anatomy, 2022 - Wiley Online Library
Neurodegenerative disorders are characterized by progressive loss of particular populations
of neurons. Apoptosis has been implicated in the pathogenesis of neurodegenerative …

[HTML][HTML] Mitochondrial transfer as a novel therapeutic approach in disease diagnosis and treatment

VJ Clemente-Suárez, A Martín-Rodríguez… - International Journal of …, 2023 - mdpi.com
Mitochondrial dysfunction is a hallmark of numerous diseases, including neurodegenerative
disorders, metabolic disorders, and cancer. Mitochondrial transfer, the transfer of …

[HTML][HTML] Mitochondrial dysfunctions: a red thread across neurodegenerative diseases

S Stanga, A Caretto, M Boido, A Vercelli - International journal of …, 2020 - mdpi.com
Mitochondria play a central role in a plethora of processes related to the maintenance of
cellular homeostasis and genomic integrity. They contribute to preserving the optimal …

[HTML][HTML] Current and future therapeutic strategies for Alzheimer's disease: An overview of drug development bottlenecks

Y Peng, H Jin, Y Xue, Q Chen, S Yao… - Frontiers in aging …, 2023 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is the most common chronic neurodegenerative disease
worldwide. It causes cognitive dysfunction, such as aphasia and agnosia, and mental …

[HTML][HTML] Mitochondria and brain disease: a comprehensive review of pathological mechanisms and therapeutic opportunities

VJ Clemente-Suárez, L Redondo-Flórez… - Biomedicines, 2023 - mdpi.com
Mitochondria play a vital role in maintaining cellular energy homeostasis, regulating
apoptosis, and controlling redox signaling. Dysfunction of mitochondria has been implicated …

The role of inflammation in neurological disorders

D Degan, R Ornello, C Tiseo, A Carolei… - Current …, 2018 - ingentaconnect.com
Traditionally neurological diseases have been classified, on the basis of their pathogenesis,
into vascular, degenerative, inflammatory and traumatic diseases. Examples of the main …