Alzheimer's disease and its treatment by different approaches: A review
Alzheimer's disease (AD) is a neurodegenerative disorder that impairs mental ability
development and interrupts neurocognitive function. This neuropathological condition is …
development and interrupts neurocognitive function. This neuropathological condition is …
[HTML][HTML] New insights into the complex role of mitochondria in Parkinson's disease
New discoveries providing insights into mitochondrial bioenergetics, their dynamic
interactions as well as their role in cellular homeostasis have dramatically advanced our …
interactions as well as their role in cellular homeostasis have dramatically advanced our …
[HTML][HTML] Mitochondria as potential targets in Alzheimer disease therapy: an update
G Cenini, W Voos - Frontiers in pharmacology, 2019 - frontiersin.org
Alzheimer disease (AD) is a progressive and deleterious neurodegenerative disorder that
affects mostly the elderly population. At the moment, no effective treatments are available in …
affects mostly the elderly population. At the moment, no effective treatments are available in …
[HTML][HTML] Mitochondrial-derived vesicles compensate for loss of LC3-mediated mitophagy
Mitochondria are critical metabolic and signaling hubs, and dysregulated mitochondrial
homeostasis is implicated in many diseases. Degradation of damaged mitochondria by …
homeostasis is implicated in many diseases. Degradation of damaged mitochondria by …
Apoptosis and its therapeutic implications in neurodegenerative diseases
NS Erekat - Clinical Anatomy, 2022 - Wiley Online Library
Neurodegenerative disorders are characterized by progressive loss of particular populations
of neurons. Apoptosis has been implicated in the pathogenesis of neurodegenerative …
of neurons. Apoptosis has been implicated in the pathogenesis of neurodegenerative …
[HTML][HTML] Mitochondrial transfer as a novel therapeutic approach in disease diagnosis and treatment
VJ Clemente-Suárez, A Martín-Rodríguez… - International Journal of …, 2023 - mdpi.com
Mitochondrial dysfunction is a hallmark of numerous diseases, including neurodegenerative
disorders, metabolic disorders, and cancer. Mitochondrial transfer, the transfer of …
disorders, metabolic disorders, and cancer. Mitochondrial transfer, the transfer of …
[HTML][HTML] Mitochondrial dysfunctions: a red thread across neurodegenerative diseases
Mitochondria play a central role in a plethora of processes related to the maintenance of
cellular homeostasis and genomic integrity. They contribute to preserving the optimal …
cellular homeostasis and genomic integrity. They contribute to preserving the optimal …
[HTML][HTML] Current and future therapeutic strategies for Alzheimer's disease: An overview of drug development bottlenecks
Y Peng, H Jin, Y Xue, Q Chen, S Yao… - Frontiers in aging …, 2023 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is the most common chronic neurodegenerative disease
worldwide. It causes cognitive dysfunction, such as aphasia and agnosia, and mental …
worldwide. It causes cognitive dysfunction, such as aphasia and agnosia, and mental …
[HTML][HTML] Mitochondria and brain disease: a comprehensive review of pathological mechanisms and therapeutic opportunities
VJ Clemente-Suárez, L Redondo-Flórez… - Biomedicines, 2023 - mdpi.com
Mitochondria play a vital role in maintaining cellular energy homeostasis, regulating
apoptosis, and controlling redox signaling. Dysfunction of mitochondria has been implicated …
apoptosis, and controlling redox signaling. Dysfunction of mitochondria has been implicated …
The role of inflammation in neurological disorders
Traditionally neurological diseases have been classified, on the basis of their pathogenesis,
into vascular, degenerative, inflammatory and traumatic diseases. Examples of the main …
into vascular, degenerative, inflammatory and traumatic diseases. Examples of the main …