From antibacterial to antibiofilm targeting: an emerging paradigm shift in the development of quaternary ammonium compounds (QACs)

EA Saverina, NA Frolov, OA Kamanina… - ACS Infectious …, 2023 - ACS Publications
In a previous development stage, mostly individual antibacterial activity was a target in the
optimization of biologically active compounds and antiseptic agents. Although this targeting …

[HTML][HTML] The current knowledge on the pathogenesis of tissue and medical device-related biofilm infections

EG Di Domenico, A Oliva, M Guembe - Microorganisms, 2022 - mdpi.com
Biofilm is the trigger for the majority of infections caused by the ability of microorganisms to
adhere to tissues and medical devices. Microbial cells embedded in the biofilm matrix are …

[HTML][HTML] How biofilm changes our understanding of cleaning and disinfection

JY Maillard, I Centeleghe - Antimicrobial Resistance & Infection Control, 2023 - Springer
Biofilms are ubiquitous in healthcare settings. By nature, biofilms are less susceptible to
antimicrobials and are associated with healthcare-associated infections (HAI). Resistance of …

[HTML][HTML] Antibiotic adjuvants: Synergistic tool to combat multi-drug resistant pathogens

V Kumar, N Yasmeen, A Pandey… - Frontiers in Cellular …, 2023 - frontiersin.org
The rise of multi-drug resistant (MDR) pathogens poses a significant challenge to the field of
infectious disease treatment. To overcome this problem, novel strategies are being explored …

[HTML][HTML] Prediction of the synergistic effect of antimicrobial peptides and antimicrobial agents via supervised machine learning

B Olcay, GD Ozdemir, MA Ozdemir, UK Ercan… - BMC Biomedical …, 2024 - Springer
Background Infectious diseases not only cause severe health problems but also burden the
healthcare system. Therefore, the effective treatment of those diseases is crucial. Both …

[HTML][HTML] Liposomes-based drug delivery systems of anti-biofilm agents to combat bacterial biofilm formation

Z Makhlouf, AA Ali, MH Al-Sayah - Antibiotics, 2023 - mdpi.com
All currently approved antibiotics are being met by some degree of resistance by the
bacteria they target. Biofilm formation is one of the crucial enablers of bacterial resistance …

[HTML][HTML] Bacterial infections among patients with chronic diseases at a tertiary care hospital in Saudi Arabia

AS Bazaid, AA Punjabi, A Aldarhami, H Qanash… - Microorganisms, 2022 - mdpi.com
Infections caused by multi-drug-resistant bacteria in patients with chronic diseases have
been associated with high mortality and morbidity. While few reports have evaluated …

[HTML][HTML] Alteration of oral microbial biofilms by sweeteners

GJ Jeong, F Khan, N Tabassum, YM Kim - Biofilm, 2023 - Elsevier
There is a growing interest in using sweeteners for taste improvement in the food and drink
industry. Sweeteners were found to regulate the formation or dispersal of structural …

[HTML][HTML] Combination drug strategies for biofilm eradication using synthetic and natural agents in KAPE pathogens

AK Bari, TS Belalekar, A Poojary… - Frontiers in Cellular and …, 2023 - frontiersin.org
Antibiotic resistance is a global threat caused by factors such as overuse of antibiotics, lack
of awareness, development of biofilms etc. World Health Organization released a list of …

Antimicrobial, antibiofilm, and antivirulence properties of Eisenia bicyclis-extracts and Eisenia bicyclis-gold nanoparticles towards microbial pathogens

DK Oh, F Khan, SK Park, DM Jo, NG Kim, WK Jung… - Microbial …, 2024 - Elsevier
Nanomaterials derived from seaweed have developed as an alternative option for fighting
infections caused by biofilm-forming microbial pathogens. This research aimed to discover …