PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer
A Glaviano, ASC Foo, HY Lam, KCH Yap, W Jacot… - Molecular cancer, 2023 - Springer
Abstract The PI3K/AKT/mTOR (PAM) signaling pathway is a highly conserved signal
transduction network in eukaryotic cells that promotes cell survival, cell growth, and cell …
transduction network in eukaryotic cells that promotes cell survival, cell growth, and cell …
Advances in our understanding of the molecular mechanisms of action of cisplatin in cancer therapy
PB Tchounwou, S Dasari, FK Noubissi… - Journal of …, 2021 - Taylor & Francis
Cisplatin and other platinum-based chemotherapeutic drugs have been used extensively for
the treatment of human cancers such as bladder, blood, breast, cervical, esophageal, head …
the treatment of human cancers such as bladder, blood, breast, cervical, esophageal, head …
Targeting PI3K in cancer: mechanisms and advances in clinical trials
Abstract Phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR)
signaling is one of the most important intracellular pathways, which can be considered as a …
signaling is one of the most important intracellular pathways, which can be considered as a …
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals
Here we conducted a large-scale genetic association analysis of educational attainment in a
sample of approximately 1.1 million individuals and identify 1,271 independent genome …
sample of approximately 1.1 million individuals and identify 1,271 independent genome …
Lagerstroemia speciosa (L.) Pers. triggers oxidative stress mediated apoptosis via intrinsic mitochondrial pathway in HepG2 cells
RS Thakur, E Devaraj - Environmental Toxicology, 2020 - Wiley Online Library
Hepatocellular carcinoma is the second leading cause of cancer‐related mortality
worldwide. Lagerstroemia speciosa Pers.(Lythraceae) commonly known as Banaba has …
worldwide. Lagerstroemia speciosa Pers.(Lythraceae) commonly known as Banaba has …
Inflammaging and oxidative stress in human diseases: from molecular mechanisms to novel treatments
L Zuo, ER Prather, M Stetskiv, DE Garrison… - International journal of …, 2019 - mdpi.com
It has been proposed that a chronic state of inflammation correlated with aging known as
inflammaging, is implicated in multiple disease states commonly observed in the elderly …
inflammaging, is implicated in multiple disease states commonly observed in the elderly …
The pathogenic role of PI3K/AKT pathway in cancer onset and drug resistance: an updated review
F Rascio, F Spadaccino, MT Rocchetti, G Castellano… - Cancers, 2021 - mdpi.com
Simple Summary Drug resistance remains one of the major problems in cancer therapy and
is responsible for up to 90% of cancer-related deaths. It exists across all types of cancer and …
is responsible for up to 90% of cancer-related deaths. It exists across all types of cancer and …
PI3K inhibitors in cancer: clinical implications and adverse effects
The phospatidylinositol-3 kinase (PI3K) pathway is a crucial intracellular signaling pathway
which is mutated or amplified in a wide variety of cancers including breast, gastric, ovarian …
which is mutated or amplified in a wide variety of cancers including breast, gastric, ovarian …
[HTML][HTML] Mitochondrial sirtuins, metabolism, and aging
Maintaining metabolic homeostasis is essential for cellular and organismal health
throughout life. Multiple signaling pathways that regulate metabolism also play critical roles …
throughout life. Multiple signaling pathways that regulate metabolism also play critical roles …
The relation between PI3K/AKT signalling pathway and cancer
Abstract Phosphatidylinositol 3-kinases (PI3Ks) are crucial coordinators of intracellular
signalling in response to the extracellular stimulators. Hyperactivation of PI3K signalling …
signalling in response to the extracellular stimulators. Hyperactivation of PI3K signalling …