As invaluable as the standard 2-dimensional (2D) monolayer in vitro cell culture system has
been, there is increasing evidence that 3-dimensional (3D) non-adherent conditions are …

Type I collagen (Col1) is the most abundant protein in mammals. Col1 contributes to 90% of
the total organic component of bone matrix. However, the precise cellular origin and …

Alveolar bone is the thickened ridge of jaw bone that supports teeth. It is subject to constant
occlusal force and pathogens invasion, and is therefore under active bone remodeling and …

The skeleton is diverse in its functions, which include mechanical support, movement, blood
cell production, mineral storage and endocrine regulation. This multifaceted role is achieved …

Tissue function depends on cellular organization. While the properties of individual cells are
increasingly being deciphered using powerful single-cell sequencing technologies …

Bone stroma contributes to the regulation of osteogenesis and hematopoiesis but also to
fracture healing and disease processes. Mesenchymal stromal cells from bone (BMSCs) …

A lack of models that recapitulate the complexity of human bone marrow has hampered
mechanistic studies of normal and malignant hematopoiesis and the validation of novel …

The bone marrow contains various populations of skeletal stem cells (SSCs) in the stromal
compartment, which are important regulators of bone formation. It is well-described that …

A central feature of atherosclerosis, the most prevalent chronic vascular disease and root
cause of myocardial infarction and stroke, is leukocyte accumulation in the arterial wall …

Mammalian hematopoietic stem cells (HSCs) colonize the bone marrow during late fetal
development, and this becomes the major site of hematopoiesis after birth. However, little is …