Osteoprotegerin (OPG) is a circulating decoy receptor for RANKL, a multifunctional cytokine
essential for the differentiation of tissue-specific cells in bone and immune systems such as …

Periodontitis is commonly observed and is an important concern in dental health. It is
characterized by a multifactorial etiology, including imbalance of oral microbiota, mechanical …

Cancer has become one of the greatest threats to human health, and new technologies are
urgently needed to further clarify the mechanisms of cancer so that better detection and …

Bone regeneration originates from proliferation and differentiation of osteoprogenitors via
either endochondral or intramembranous ossification; and the regeneration capacities …

Endothelial cells (ECs) and bone marrow stromal cells (BMSCs) play crucial roles in
supporting hematopoiesis and hematopoietic regeneration. However, whether ECs are a …

Skeletal stem and progenitor cell populations are crucial for bone physiology.
Characterization of these cell types remains restricted to heterogenous bulk populations with …

Stromal cell populations that maintain hematopoietic stem and progenitor cells (HSPCs) are
generally characterized in steady-state conditions. Here, we report a comprehensive atlas of …

Objectives The heterogeneity of meniscus cells and the mechanism of meniscus
degeneration is not well understood. Here, single-cell RNA sequencing (scRNA-seq) was …

Treatment of FMS-like tyrosine kinase 3 (FLT3)-internal tandem duplication (ITD)-positive
acute myeloid leukemia (AML) remains a challenge despite the development of novel FLT3 …

Radiotherapy and chemotherapy disrupt bone vasculature, but the underlying causes and
mechanisms enabling vessel regeneration after bone marrow (BM) transplantation remain …