Pancreatic cancer continues to pose an enormous challenge to clinicians and cancer
scientists. With a more affluent world the global incidence of pancreatic cancer is rising. For …

Tyrosine kinases (TKs) are attractive targets for cancer therapy, as quite often their abnormal
signaling has been linked with tumor development and growth. Constitutive activated TKs …

Purpose Pertuzumab is a humanized monoclonal antibody inhibiting human epidermal
growth factor receptor 2 (HER2) dimerization. The aim of this phase II trial was to assess the …

Phenylacetylenes are key structural motifs in organic chemistry, which find widespread
applications in bioactive molecules, synthetic intermediates, functional materials, and …

Icotinib, one of the leading compounds selected from our compound library, was found to be
a potent and specific epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) …

This multicenter phase I study aimed to establish the recommended dose (RD) of the
epidermal growth factor receptor (EGFR) inhibitor erlotinib, given as monotherapy or with …

Drug transit through the blood-brain barrier (BBB) is essential for therapeutic responses in
malignant glioma. Conventional methods for assessment of BBB penetrance require …

BACKGROUND. Epidermal growth factor receptor (EGFR) inhibitors are effective cancer
therapies, but they are reported to cause a rash in> 50% of patients. In the current study, the …

Small molecule tyrosine kinase inhibitors (TKIs) are developed to block intracellular
signaling pathways in tumor cells, leading to deregulation of key cell functions such as …

This article describes recent advances in the development and biological evaluation of small
molecule inhibitors for the serine/threonine kinase Akt (PKB) as a reprise of our 2005 review …