Review on EGFR-ERK1/2 signaling cascade: implications on cell proliferation in health and disease

ME Abo-El Fetoh, MM Abdel-Fattah… - Egyptian …, 2023 - journals.lww.com
Epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that is often increased
in malignancies such as non–small cell lung cancer, metastatic colorectal cancer, head and …

[HTML][HTML] Targeted therapy for metastatic renal carcinoma: an update

RD da Silva, D Gustafson, L Nogueira… - Journal of Kidney …, 2014 - ncbi.nlm.nih.gov
Conventional chemotherapy is associated with poor outcomes in metastatic renal cell
carcinoma (RCC). Advances in the understanding of tumor molecular biology and the …

唑来膦酸联合厄罗替尼治疗非小细胞肺癌骨转移临床疗效观察

安丽, 陈石 - 海南医学, 2011 - cqvip.com
目的观察唑来膦酸联合厄罗替尼治疗晚期非小细胞肺癌(NSCLC) 骨转移的疗效及安全性,
并进行相关文献复习. 方法将60 例NSCLC 晚期骨转移患者随机分为两组, 唑来膦酸组30 例 …

The pancreatic cancer proteome–recent advances and future promise

M Aspinall‐O'Dea, E Costello - PROTEOMICS–Clinical …, 2007 - Wiley Online Library
Of the common cancers, pancreatic ductal adenocarcinoma is one of the most lethal. The
cancer's aggressive biology, leading to rapid dissemination, combined with a lack of clearly …

[PDF][PDF] 厄洛替尼治疗晚期非小细胞肺癌的临床研究

王同杉, 孙婧, 高雯, 沈华, 李晓东, 殷咏梅, 束永前… - 2009 - scholar.archive.org
背景与目的厄洛替尼在NSCLC 患者中已有广泛应用, 并能使部分NSCLC 患者明显获益.
本研究探讨厄洛替尼单药一线或二, 三线治疗晚期非小细胞肺癌的临床疗效及毒副反应 …

[HTML][HTML] Systems-level biomarkers identification and drug repositioning in colorectal cancer

H Beklen, E Yildirim, M Kori, B Turanli… - World Journal of …, 2021 - ncbi.nlm.nih.gov
Colorectal cancer (CRC) is the most commonly diagnosed fatal cancer in both women and
men worldwide. CRC ranked second in mortality and third in incidence in 2020. It is difficult …

Erlotinib‐induced florid acneiform rash complicated by extensive impetiginization

SH Kardaun, KF Van Duinen - Clinical and experimental …, 2008 - academic.oup.com
Erlotinib (Tarceva™) is an epidermal growth factor receptor (EGFR) inhibitor, a member of a
new group of molecular targeted drugs that combine high efficacy against tumours with less …

Epidermal growth factor receptor (EGFR) inhibitor-induced rash: a consecutive patient series that illustrates the need for rigorous palliative trials

BM Solomon, A Jatoi - Journal of Palliative Medicine, 2011 - liebertpub.com
Purpose: Rash is the most common side effect of epidermal growth factor receptor (EGFR)
inhibitors and negatively impacts quality of life. This single-institution study sought to explore …

Novel cytochrome p450 bioactivation of a terminal phenyl acetylene group: formation of a one-carbon loss benzaldehyde and other oxidative products in the presence …

R Subramanian, J Tam, D Aidasani… - Chemical research in …, 2011 - ACS Publications
Compounds 1 (N 1-(3-ethynylphenyl)-6-methyl-N 5-(3-(6-(methylamino) pyrimidin-4-yl)
pyridin-2-yl) isoquinoline-1, 5-diamine) and 2 (N-(3-ethynylphenyl)-6, 7-bis (2 …

[HTML][HTML] 中西医与分子靶向综合治疗胰腺癌的进展

曹志成 - 世界华人消化杂志, 2006 - wjgnet.com
胰腺癌预后不良, 死亡率高居消化道癌症第5 位. 现代医学对胰腺癌的病因尚未完全清楚,
但随着肿瘤发生, 发展分子机制的逐步了解, 癌细胞与正常细胞的区别将会更加明确 …