Fibroblast growth factors (FGFs) are a family of heparin-binding growth factors. FGFs exert
their pro-angiogenic activity by interacting with various endothelial cell surface receptors …

Biological processes that drive cell growth are exciting targets for cancer therapy. The
fibroblast growth factor (FGF) signaling network plays a ubiquitous role in normal cell …

Although fibroblast growth factors are potent angiogenic factors, they may indirectly control
neovascularization in concert with other growth factors. Thus, the unique role played by …

Abstract The PI3K/AKT signaling pathway is aberrant in a wide variety of cancers.
Downstream effectors of AKT are involved in survival, growth and metabolic-related …

Angiogenesis, the process of formation of new blood vessel from pre-existing ones, is
involved in various intertwined pathological processes including virus infection …

Numerous studies have suggested a link between the angiogenic FGF and VEGF signaling
pathways; however, the nature of this link has not been established. To evaluate this …

Myocardial infarction and ischemic heart disease are the leading cause of death in the
industrial world. Therapies employed for treating these diseases are aimed at promoting …

Purpose: The oncogenic drivers of triple-negative (TN) and basal-like breast cancers are
largely unknown. Substantial evidence now links aberrant signaling by the fibroblast growth …

Angiogenesis provides a mechanism by which delivery of oxygen and nutrients is adapted
to compliment changes in tissue mass or metabolic activity. However, maladaptive …

The structural and catalytic requirements for neutrophil MMP-9 proenzyme (proMMP-9) to
induce angiogenesis were investigated using a quantitative angiogenesis model based on …