The cochlear matrisome: Importance in hearing and deafness

MT Pressé, B Malgrange, L Delacroix - Matrix Biology, 2023 - Elsevier
The extracellular matrix (ECM) consists in a complex meshwork of collagens, glycoproteins,
and proteoglycans, which serves a scaffolding function and provides viscoelastic properties …

Improved Cochlear Implant Performance Estimation Using Tonotopic-Based Electrocochleography

A Walia, MA Shew, J Varghese, P Ioerger… - … –Head & Neck …, 2023 - jamanetwork.com
Importance Cochlear implantation produces remarkable results in postlingual deafness,
although auditory outcomes vary. Electrocochleography (ECochG) has emerged as a …

[HTML][HTML] Artifact removal by template subtraction enables recordings of the frequency following response in cochlear-implant users

R Gransier, RP Carlyon, ML Richardson… - Scientific reports, 2024 - nature.com
Electrically evoked frequency-following responses (eFFRs) provide insight in the phase-
locking ability of brainstem of cochlear-implant (CI) users. eFFRs can potentially be used to …

[HTML][HTML] Tripolar configuration and pulse shape in cochlear implants reduce channel interactions in the temporal domain

GL Quass, A Kral - Hearing Research, 2024 - Elsevier
The present study investigates effects of current focusing and pulse shape on threshold,
dynamic range, spread of excitation and channel interaction in the time domain using …

[HTML][HTML] Potential uses of auditory nerve stimulation to modulate immune responses in the inner ear and auditory brainstem

BJ Seicol, Z Guo, K Garrity, R Xie - Frontiers in Integrative …, 2023 - ncbi.nlm.nih.gov
Bioelectronic medicine uses electrical stimulation of the nervous system to improve health
outcomes throughout the body primarily by regulating immune responses. This concept …

Trametinib, a MEK1/2 Inhibitor, Protects Mice from Cisplatin-and Noise-Induced Hearing Loss

RD Lutze, MA Ingersoll, RG Kelmann, T Teitz - Pharmaceuticals, 2024 - mdpi.com
Hearing loss is one of the most common types of disability; however, there is only one FDA-
approved drug to prevent any type of hearing loss. Treatment with the highly effective …

[HTML][HTML] Insights Into Electrophysiological Metrics of Cochlear Health in Cochlear Implant Users Using a Computational Model

M Takanen, S Strahl, K Schwarz - Journal of the Association for Research …, 2024 - Springer
Purpose The hearing outcomes of cochlear implant users depend on the functional status of
the electrode-neuron interface inside the cochlea. This can be assessed by measuring …

[HTML][HTML] The grand challenge at the frontiers of neurotechnology and its emerging clinical applications

R Bhidayasiri - Frontiers in Neurology, 2024 - frontiersin.org
When I commenced my medical training, I could never have imagined the huge advances
that would be made in the intervening years in the use of technology across all fields of …

FDA-Approved MEK1/2 Inhibitor, Trametinib, Protects Mice from Cisplatin and Noise-Induced Hearing Loss

RD Lutze, MA Ingersoll, RG Kelmann, T Teitz - bioRxiv, 2024 - biorxiv.org
Hearing loss is one of the most common types of disability; however, there is only one FDA-
approved drug to prevent any type of hearing loss. Treatment with the highly effective …

[HTML][HTML] The Assessment of Electrode-Neuron Interface (ENI) in Cochlear Implant Users

M Maarefvand - 2023 - intechopen.com
The electrode-neuron interface (ENI) plays an important in the outcome with cochlear
implants as all cochlear implant-mediated signals should pass through this interface …