The role of mitochondrial sirtuins (sirt3, sirt4 and sirt5) in renal cell metabolism: Implication for kidney diseases

F Juszczak, T Arnould, AE Declèves - International Journal of Molecular …, 2024 - mdpi.com
Kidney diseases, including chronic kidney disease (CKD), diabetic nephropathy, and acute
kidney injury (AKI), represent a significant global health burden. The kidneys are …

[HTML][HTML] Comprehensive review of perioperative factors influencing ferroptosis

CH Fan, XQ Zeng, RM Feng, HW Yi, R Xia - Biomedicine & …, 2024 - Elsevier
The perioperative period encompasses all phases of patient care from the decision to
perform surgery until full recovery. Ferroptosis, a newly identified type of regulated cell …

PRMT7-Dependent Transcriptional Activation of Hmgb2 Aggravates Severe Acute Pancreatitis by Promoting Acsl1-Induced Ferroptosis

M Su, F Chen, D Han, M Song… - Journal of Proteome …, 2024 - ACS Publications
Severe acute pancreatitis (SAP) is a highly fatal abdominal emergency, and its association
with protein arginine methyltransferase 7 (PRMT7), the sole known type III enzyme …

[HTML][HTML] The potential roles of HIF-1α in epithelial-mesenchymal transition and ferroptosis in tumor cells

Z Shen, N Yu, Y Zhang, M Jia, Y Sun, Y Li, L Zhao - Cellular Signalling, 2024 - Elsevier
In tumors, the rapid proliferation of cells and the imperfect blood supply system lead to
hypoxia, which can regulate the adaptation of tumor cells to the hypoxic environment …

mTORC2 knockdown mediates lipid metabolism to alleviate hyperlipidemic pancreatitis through PPARα

X Wang, Y Liu, Y Zhou, M Li, T Mo, X Xu… - … of Biochemical and …, 2024 - Wiley Online Library
Hyperlipidemic pancreatitis (HP) is an inflammatory injury of the pancreas triggered by
elevated serum triglyceride (TG) levels. The mechanistic target of rapamycin (mTOR) …

The role of ferroptosis in acute kidney injury: mechanisms and potential therapeutic targets

Y Yu, L Zhang, D Zhang, Q Dai, M Hou, M Chen… - Molecular and Cellular …, 2024 - Springer
Acute kidney injury (AKI) is one of the most common and severe clinical renal syndromes
with high morbidity and mortality. Ferroptosis is a form of programmed cell death (PCD), is …

Roles of Sirtuins in Hearing Protection.

C Koo, CP Richter, X Tan - Pharmaceuticals (14248247), 2024 - search.ebscohost.com
Hearing loss is a health crisis that affects more than 60 million Americans. Currently, sodium
thiosulfate is the only drug approved by the Food and Drug Administration (FDA) to counter …

基于铁死亡的糖尿病肾病发病机制及中药干预的研究进展.

樊俐慧, 王志刚, 杨霞, 张坤… - Traditional Chinese Drug …, 2024 - search.ebscohost.com
糖尿病肾病(diabetic kidney disease, DKD) 是全球终末期肾病的主要原因,
是糖尿病的主要微血管并发症之一. DKD 的发病机制是多因素的, 其病理过程涉及多种途径 …

In vitro effects of Ganoderic acid A on NF-κB-mediated inflammatory response in caerulein-stimulated pancreatic acinar cells.

Y Jin, J Huang, N Ma - Signa Vitae, 2024 - search.ebscohost.com
This study aimed to investigate Ganoderic acid A's (GAA) possible effects on inflammation
and oxidative stress of caerulein-stimulated pancreatic acinar cells and uncover its effects …