Biogenesis, isolation, and detection of exosomes and their potential in therapeutics and Diagnostics

S Sonbhadra, Mehak, LM Pandey - Biosensors, 2023 - mdpi.com
The increasing research and rapid developments in the field of exosomes provide insights
into their role and significance in human health. Exosomes derived from various sources …

Structural, kinetic, and thermodynamic aspects of insulin aggregation

C Panda, S Kumar, S Gupta, LM Pandey - … Chemistry Chemical Physics, 2023 - pubs.rsc.org
Given the significance of protein aggregation in proteinopathies and the development of
therapeutic protein pharmaceuticals, revamped interest in assessing and modelling the …

Polymer-mediated Protein/Peptide Therapeutic Stabilization: Current Progress and Future Directions

RP Sivasankaran, K Snell, G Kunkel, P Georgiou… - Progress in Polymer …, 2024 - Elsevier
Proteins and peptides have played a pivotal role in revolutionizing disease treatment over
the last century. Despite their commercial success, protein therapeutics can be eliminated or …

Unfolding of the SARS-CoV-2 spike protein through infrared and ultraviolet-C radiation based disinfection

N Mahanta, S Sharma, LG Sharma, LM Pandey… - International Journal of …, 2022 - Elsevier
The spreading of coronavirus from contacting surfaces and aerosols created a pandemic
around the world. To prevent the transmission of SARS-CoV-2 virus and other contagious …

[HTML][HTML] Experimental procedures to investigate fibrillation of proteins

C Panda, LG Sharma, LM Pandey - MethodsX, 2023 - Elsevier
The unwanted phenomenon of protein fibrillation is observed in vivo and during therapeutic
protein development in the industry. Protein aggregation is associated with various …

Insulin fibrillation under physicochemical parameters of bioprocessing and intervention by peptides and surface-active agents

C Panda, S Kumar, S Gupta… - Critical Reviews in …, 2024 - Taylor & Francis
Even after the centenary celebration of insulin discovery, there prevail challenges
concerning insulin aggregation, not only after repeated administration but also during …

Effects of Lactobacillus plantarum-fermented soy whey composite/huajiao seed antimicrobial peptides/inulin composites on konjac gel preservation

Z Xiao, X Huang, Z Liu, J Xie, Z Rasheed, J Yan… - Food Packaging and …, 2024 - Elsevier
To extend the shelf life of konjac gels, this study investigated the effects of preservatives
prepared using food production byproducts. First, the ultrasonic and microwave-assisted …

Optimizing a therapeutic humanized follicle‐stimulating hormone–blocking antibody formulation by protein thermal shift assay

D Sant, S Rojekar, S Gera, AR Pallapati… - 2023 - Wiley Online Library
Biopharmaceutical products are formulated using several Food and Drug Administration
(FDA) approved excipients within the inactive ingredient limit to maintain their storage …

[HTML][HTML] Lyophilization of biomimetic amyloids preserves their regulatable, endocrine-like functions for nanoparticle release

MTP Favaro, H López-Laguna, E Voltà-Durán… - Applied Materials …, 2024 - Elsevier
The secretory granules from the mammalian endocrine system are functional amyloids that
act as dynamic depots to store and release protein hormones into the bloodstream. The …

Natural lipopeptide surfactin inhibits insulin aggregation and prevents amyloid-induced cytotoxicity and inflammation

C Panda, S Dumka, S Kumar, S Gupta… - Journal of Molecular …, 2024 - Elsevier
Despite the centennial of the pioneering discovery of insulin, challenges regarding insulin
aggregation at the site of repeated injection, as well as during industrial production, storage …