Syringin Prevents 6-Hydroxydopamine Neurotoxicity by Mediating the MiR-34a/SIRT1/Beclin-1 Pathway and Activating Autophagy in SH-SY5Y Cells and the …

RH Fu, SY Hong, HJ Chen - Cells, 2023 - mdpi.com
Defective autophagy is one of the cellular hallmarks of Parkinson's disease (PD). Therefore,
a therapeutic strategy could be a modest enhancement of autophagic activity in dopamine …

In situ stoichiometry amounts of p62 and poly-ubiquitin exceed the increase of alpha-synuclein during degeneration of catecholamine cells induced by autophagy …

P Lenzi, G Lazzeri, M Ferrucci, CL Busceti… - Journal of Neural …, 2024 - Springer
Neurodegenerative disorders are typically featured by the occurrence of neuronal
inclusions. In the case of Parkinson's disease (PD) these correspond to Lewy bodies (LBs) …

[HTML][HTML] Defective autophagic flux aggravates cadmium-induced Sertoli cell apoptosis

N Chen, X Wan, S Cheng, G Tang, D Xia, Y Xu… - Ecotoxicology and …, 2024 - Elsevier
The male reproductive dysfunction accounts for 50% of infertile couples in the world.
Cadmium (Cd) is one of the most harmful heavy metals to both the environment and …

Autophagy and UPS pathway contribute to nicotine-induced protection effect in Parkinson's disease

I Ullah, S Uddin, L Zhao, X Wang, H Li - Experimental Brain Research, 2024 - Springer
The gradual nature of age-related neurodegeneration causes Parkinson's disease (PD) and
impairs movement, memory, intellectual ability, and social interaction. One of the most …