Delivery of biologics via cerebrospinal fluid (CSF) has demonstrated potential to access the
tissues of the central nervous system (CNS) by circumventing the blood‐brain barrier and …

Intrathecal delivery (IT) of opiates into the cerebrospinal fluid (CSF) for anesthesia and pain
relief has been used clinically for decades, but this relatively straightforward approach of …

The kinetics of amyloid beta turnover within human brain is still poorly understood. We
previously found a dramatic decline in the turnover of Aβ peptides in normal aging. It was not …

Non-equilibrium evolution of wave fields, as occurring over sudden bathymetry variations,
can produce rogue seas with anomalous wave statistics. We handle this process by …

Background Intrathecal drug delivery has a significant role in pain management and central
nervous system (CNS) disease therapeutics. A fluid-physics based tool to assist clinicians in …

Advances in our understanding of the biology of spinal systems in organizing and defining
the content of exteroceptive information upon which higher centers define the state of the …

The monitoring of intracranial pressure (ICP) fluctuations, which is needed in the context of a
number of neurological diseases, requires the insertion of pressure sensors, an invasive …

BACKGROUND AND PURPOSE: Forced respirations reportedly have an effect on CSF
movement in the spinal canal. We studied respiratory-related CSF motion during normal …

This paper investigates the transport of a solute carried by the cerebrospinal fluid (CSF) in
the spinal canal. The analysis is motivated by the need for a better understanding of drug …

Background: Traditionally, there is a widely held belief that drug dispersion after intrathecal
(IT) delivery is confined locally near the injection site. We posit that high-volume infusions …