Stroke is a leading cause of human death and disability in the USA and around the world.
Shortly after the cerebral ischemia, cell swelling is the earliest morphological change in …

The evasion from controlled cell death induction has been considered as one of the
hallmarks of cancer cells. Defects in cell death signaling are a fundamental phenomenon in …

The pancreatic cancer is the fourth leading cause of cancer-related death and characterized
by one of the lowest five-year survival rate. The current therapeutic options are …

Abstract The dismal 5-year survival (< 5%) for pancreatic cancer (PanCA) underscores the
need for developing effective therapeutic options. Recent studies from our laboratory have …

Cigarette smoking is a major risk factor for the inflammatory disease, chronic obstructive
pulmonary disease (COPD). The mechanism by which cigarette smoke (CS) induces chronic …

Purpose Ischemia-reperfusion (IR) injury is involved in the pathology of many retinal
disorders since it contributes to the death of retinal neurons and the subsequent decline in …

The current study investigated the prophylactic effect of ethyl pyruvate (EP) in Isoproterenol
(ISO)-induced myocardial infarction (MI). Ethyl pyruvate (EP) was given at a dose of 100 …

Progression through the cell cycle is one of the most important decisions during the life of a
cell and several kinds of stress are able to influence this choice. p57 is a cyclin‐dependent …

We provide first-time evidence for ERβ-mediated transcriptional upregulation of c-FLIP as an
underlying mechanism in the development of castrate-resistant cancer. While androgens …

Glycogen synthase kinase-3β (GSK-3β) is a ubiquitously expressed serine/threonine kinase
involved in a variety of functions ranging from the control of glycogen metabolism to …