Neuroinflammation and necroptosis are major contributors to neurodegenerative disease,
and axon dysfunction and degeneration is often an initiating event. SARM1 is the central …

The approval of the first small interfering RNA (siRNA) drug Patisiran by FDA in 2018 marks
a new era of RNA interference (RNAi) therapeutics. MicroRNAs (miRNA), an important post …

Regulatory programs governing neuronal death and axon regeneration in
neurodegenerative diseases remain poorly understood. In adult mice, optic nerve crush …

Background Glaucoma, the major cause of irreversible blindness worldwide, is
characterized by progressive degeneration of retinal ganglion cells (RGCs). Current …

In an elegant example of bench-to-bedside research, a hypothesis that cells in the outflow
pathway actively regulate conventional outflow resistance was proposed in the 1990s and …

Normal tension glaucoma (NTG) is an exception in the “glaucoma family” where the major
risk factor, increased intraocular pressure, is missing. If not increased intraocular pressure …

Research in the development of ophthalmic drug formulations and innovative technologies
over the past few decades has been directed at improving the penetration of medications …

Purpose To compare the diagnostic abilities of the vessel densities in optic nerve head
(ONH), peripapillary, and macular regions measured using optical coherence tomography …

Glaucoma is the result of the gradual death of retinal ganglion cells (RGCs) whose axons
form the optic nerve. Elevated intraocular pressure (IOP) is a major risk factors …

Purpose: The purpose of this study was to assess the long-term effectiveness and safety of
the PRESERFLO MicroShunt (8.5 mm long, 70 µm lumen surgical device, formerly known as …