Interferon-induced transmembrane protein 3 (IFITM3) and its antiviral activity

I Jimenez-Munguia, AH Beaven, PS Blank… - Current Opinion in …, 2022 - Elsevier
Infections caused by enveloped viruses require fusion with cellular membranes for viral
genome entry. Viral entry occurs following an interaction of viral and cellular membranes …

Illuminating membrane structural dynamics of fusion and endocytosis with advanced light imaging techniques

CY Chan, Y Faragalla, LG Wu - Biochemical Society …, 2022 - portlandpress.com
Visualization of cellular dynamics using fluorescent light microscopy has become a reliable
and indispensable source of experimental evidence for biological studies. Over the past two …

[HTML][HTML] Event-triggered STED imaging

J Alvelid, M Damenti, C Sgattoni, I Testa - Nature Methods, 2022 - nature.com
Monitoring the proteins and lipids that mediate all cellular processes requires imaging
methods with increased spatial and temporal resolution. STED (stimulated emission …

Lipids and secretory vesicle exocytosis

IO Akefe, SL Osborne, B Matthews, TP Wallis… - Molecular Mechanisms …, 2023 - Springer
In recent years, the number of studies implicating lipids in the regulation of synaptic vesicle
exocytosis has risen considerably. It has become increasingly clear that lipids such as …

[HTML][HTML] Channels and transporters of the pulmonary lamellar body in health and disease

P Dietl, M Frick - Cells, 2021 - mdpi.com
The lamellar body (LB) of the alveolar type II (ATII) cell is a lysosome-related organelle
(LRO) that contains surfactant, a complex mix of mainly lipids and specific surfactant …

Regulated exocytosis from astrocytes: a matter of vesicles?

C Calì - Frontiers in Neuroscience, 2024 - frontiersin.org
The presence of secretory vesicles (synaptic-like microvesicles or SLMVs) in astrocytes
capable of fine-tuning synaptic transmission, has been a topic of debate in the field. While …

Simulated dynamic cholesterol redistribution favors membrane fusion pore constriction

AH Beaven, K Sapp, AJ Sodt - Biophysical Journal, 2023 - cell.com
Endo-and exocytosis proceed through a highly strained membrane fusion pore topology
regardless of the aiding protein machinery. The membrane's lipid components bias fusion …

PI(4,5)P2 and Cholesterol: Synthesis, Regulation, and Functions

A Rosenhouse-Dantsker, D Gazgalis… - … and PI (4, 5) P2 in Vital …, 2023 - Springer
Abstract Phosphatidylinositol 4, 5-bisphosphate (PI (4, 5) P2) is the most abundant
membrane phosphoinositide and cholesterol is an essential component of the plasma …

[HTML][HTML] Sequestration of membrane cholesterol by cholesterol-binding proteins inhibits SARS-CoV-2 entry into Vero E6 cells

M Kulma, A Šakanović, A Bedina-Zavec… - Biochemical and …, 2024 - Elsevier
Membrane lipids and proteins form dynamic domains crucial for physiological and
pathophysiological processes, including viral infection. Many plasma membrane proteins …

Barriers to exocytotic vesicle discharge

R Zorec, LG Wu - Cell Calcium, 2023 - Elsevier
Regulated exocytosis, a universal process of eukaryotic cells, involves the merging between
the vesicle membrane and the plasma membrane, plays a key role in cell-to-cell …