The evolution of cancer treatment has provided increasingly targeted strategies both in the
upfront and relapsed disease settings. Small‐molecule inhibitors and immunotherapy have …

ATAC-seq has emerged as a rich epigenome profiling technique, and is commonly used to
identify Transcription Factors (TFs) underlying given phenomena. A number of methods can …

Despite the success of drug discovery over the past decades, many potential drug targets
still remain intractable for small molecule modulation. The development of proteolysis …

Conventional small-molecule drugs (SMDs) are compounds characterized by low molecular
weight, high cell permeability, and high selectivity. In clinical translation, SMDs are regarded …

Targeting “undruggable” targets with intrinsically disordered structures is of great
significance for the treatment of disease. The transcription factor c‐Myc controls global gene …

Background Multiple genetic and epigenetic regulatory mechanisms are crucial in the
development and tumorigenesis process. Transcriptional regulation often involves intricate …

Targeted protein degradation (TPD) is a promising approach that has the ability to address
disease-causing proteins. Compared to traditional inhibition, proteolysis targeting chimera …

Proteolysis‐targeting chimeras (PROTACs) is a targeted protein degradation (TPD)
technique effected by hijacking the ubiquitin‐proteasome system (UPS) of the cells. A …

Dysfunctional transcription factors that activate abnormal expressions of specific proteins are
often associated with the progression of various diseases. Despite being attractive drug …

RNA-DNA covalent hybrids (RDHs) are widely employed in biology. Although RDHs can be
manufactured, the synthesis of molecules longer than 120 nucleotides is challenging. Here …