In sensory neurons, presynaptic voltage-gated L-type calcium channels (Cav1) mediate
calcium influx as a first important step in synaptic transmission. This review illuminates the …

Functional diversification of voltage-gated Ca2+ channels is underlain by the existence of
multiple α1-subunit-encoding genes. To define Ca2+ channel types and to understand their …

Some patients visit the doctor because of hearing problems in noise. The hearing
examination, however, does not show any specifics. Only an extended and targeted …

Background: Autosomal recessive non-syndromic hearing loss (ARNSHL), one of the global
public health concerns, is marked by a high degree of genetic heterogeneity. The role of …

Deafness in vertebrates is associated with variants of hundreds of genes. Yet, many genes
causing rare forms of deafness remain to be discovered. Microarrays and exome …

Genetic disorders of vision and hearing exhibit genetic heterogeneity. Currently used
sequential single-gene analysis allows identification of disease-causing mutations in only a …

L-type Ca 2+ channels play an important role in sensory cells present in the inner ear and
the retina. Ca v 1.3 predominates in sensory cells of the inner ear (inner and outer cochlear …

In this chapter, we discuss the factors that regulate the contributions of presynaptic voltage-
gated (CaV) Ca2+ channels to neurotransmitter release. Cav channels serve as portals for …

Reviling the etiology or at least pathophysiology of auditory neuropathy spectrum disorder is
crucial for choosing rehabilitation pathway and predicting rehabilitation outcomes. Some …

Background The genetic architecture of hearing impairment in Finland is largely unknown.
Here, we investigated two Finnish families with autosomal recessive nonsyndromic …