Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host
response to infection. Common causes include gram-negative and gram-positive bacteria as …

Several lines of evidence indicate that female sex is a protective factor in trauma and
hemorrhage. In both clinical and experimental studies, proestrus females have been shown …

Sepsis is a common serious clinical infectious disease accompanied by more severe
injuries and higher mortality rates in men than women. The much higher level of 17β …

Background: Obesity was linked to altered immunity, but also to favorable outcomes among
patients with infectious disease (ID) in some settings. We assessed the association between …

Estrogens modulate the immune system and possess anti-inflammatory properties. In line,
immune cells express a variety of estrogen receptors (ER) including ER-alpha and-beta. In …

Background Sepsis is a leading cause of mortality among patients in intensive care units
across the USA. Thioredoxin-1 (Trx-1) is an essential 12 kDa cytosolic protein that, apart …

Objectives To determine whether the age at menarche (AAM) and the age at menopause
(ANM) are causally related to the development of sepsis. Methods We performed a two …

Insulin-like growth factor-binding protein (IGFBP)-2 is a regulator of anabolic pathways,
which become inactivated in severe illness. Here, we measured the serum IGFBP-2 levels of …

Sepsis has emerged as a major global public health concern due to its elevated mortality
and high cost of care. This study aimed to evaluate the risk factors associated with the …

Patients with cancer who develop sepsis have a markedly higher mortality than patients who
were healthy prior to the onset of sepsis. Potential mechanisms underlying this difference …