Antigen processing for amateurs and professionals
The initiation and propagation of immune responses is dependent on the ability of antigen-
presenting cells (APCs) to convert proteins into peptides, to load them intracellularly onto …
presenting cells (APCs) to convert proteins into peptides, to load them intracellularly onto …
Regulation of antigen presentation and cross-presentation in the dendritic cell network: facts, hypothesis, and immunological implications
NS Wilson, JA Villadangos - Advances in immunology, 2005 - Elsevier
Dendritic cells (DCs) are central to the maintenance of immunological tolerance and the
initiation and control of immunity. The antigen-presenting properties of DCs enable them to …
initiation and control of immunity. The antigen-presenting properties of DCs enable them to …
CD40-stimulated B lymphocytes pulsed with tumor antigens are effective antigen-presenting cells that can generate specific T cells
R Lapointe, A Bellemare-Pelletier, F Housseau… - Cancer research, 2003 - AACR
Although they are considered as antigen-presenting cells, the role of antigen-unspecific B
lymphocytes in antigen presentation and T-lymphocyte stimulation remains controversial. In …
lymphocytes in antigen presentation and T-lymphocyte stimulation remains controversial. In …
Achieving stability through editing and chaperoning: regulation of MHC class II peptide binding and expression
R Busch, CH Rinderknecht, S Roh… - Immunological …, 2005 - Wiley Online Library
In antigen‐presenting cells (APCs), loading of major histocompatibility complex class II
(MHC II) molecules with peptides is regulated by invariant chain (Ii), which blocks MHC II …
(MHC II) molecules with peptides is regulated by invariant chain (Ii), which blocks MHC II …
Nonclassical MHC class II molecules
C Alfonso, L Karlsson - Annual review of immunology, 2000 - annualreviews.org
Major histocompatibility complex (MHC) class II molecules are cell surface proteins that
present peptides to CD4+ T cells. In addition to these wellcharacterized molecules, two other …
present peptides to CD4+ T cells. In addition to these wellcharacterized molecules, two other …
HLA-DO is a negative modulator of HLA-DM-mediated MHC class II peptide loading
SM Van Ham, EPM Tjin, BF Lillemeier, U Grüneberg… - Current biology, 1997 - cell.com
Background: Class II molecules of the major histocompatibility complex become loaded with
antigenic peptides after dissociation of invariant chainderived peptides (CLIP) from the …
antigenic peptides after dissociation of invariant chainderived peptides (CLIP) from the …
HLA-DM acts as a molecular chaperone and rescues empty HLA-DR molecules at lysosomal pH
H Kropshofer, SO Arndt, G Moldenhauer… - Immunity, 1997 - cell.com
Abstract HLA-DM (DM) is a nonclassical MHC class II molecule that interacts with classical
MHC II molecules in acidic compartments. During this association DM is supposed to …
MHC II molecules in acidic compartments. During this association DM is supposed to …
Presentation of antigens by MHC class II molecules: getting the most out of them
JA Villadangos - Molecular immunology, 2001 - Elsevier
The function of MHC class II molecules is to bind peptides derived from antigens that access
the endocytic route of antigen presenting cells and display them on the plasma membrane …
the endocytic route of antigen presenting cells and display them on the plasma membrane …
Cathepsin V is involved in the degradation of invariant chain in human thymus and is overexpressed in myasthenia gravis
E Tolosa, W Li, Y Yasuda, W Wienhold… - The Journal of …, 2003 - Am Soc Clin Investig
Stepwise degradation of the invariant chain (Ii) is required for the binding of antigenic
peptides to MHC class II molecules. Cathepsin (Cat) L in the murine thymus and Cat S in …
peptides to MHC class II molecules. Cathepsin (Cat) L in the murine thymus and Cat S in …
Presentation of the self antigen myelin basic protein by dendritic cells leads to experimental autoimmune encephalomyelitis
BN Dittel, I Visintin, RM Merchant… - The Journal of …, 1999 - journals.aai.org
Bone marrow (BM)-derived dendritic cells (DC) are potent stimulators of naive CD4+ T cell
activation. Because DC are efficient at Ag processing and could potentially present self Ags …
activation. Because DC are efficient at Ag processing and could potentially present self Ags …