The initiation and propagation of immune responses is dependent on the ability of antigen-
presenting cells (APCs) to convert proteins into peptides, to load them intracellularly onto …

Dendritic cells (DCs) are central to the maintenance of immunological tolerance and the
initiation and control of immunity. The antigen-presenting properties of DCs enable them to …

Although they are considered as antigen-presenting cells, the role of antigen-unspecific B
lymphocytes in antigen presentation and T-lymphocyte stimulation remains controversial. In …

In antigen‐presenting cells (APCs), loading of major histocompatibility complex class II
(MHC II) molecules with peptides is regulated by invariant chain (Ii), which blocks MHC II …

Major histocompatibility complex (MHC) class II molecules are cell surface proteins that
present peptides to CD4+ T cells. In addition to these wellcharacterized molecules, two other …

Background: Class II molecules of the major histocompatibility complex become loaded with
antigenic peptides after dissociation of invariant chainderived peptides (CLIP) from the …

Abstract HLA-DM (DM) is a nonclassical MHC class II molecule that interacts with classical
MHC II molecules in acidic compartments. During this association DM is supposed to …

The function of MHC class II molecules is to bind peptides derived from antigens that access
the endocytic route of antigen presenting cells and display them on the plasma membrane …

Stepwise degradation of the invariant chain (Ii) is required for the binding of antigenic
peptides to MHC class II molecules. Cathepsin (Cat) L in the murine thymus and Cat S in …

Bone marrow (BM)-derived dendritic cells (DC) are potent stimulators of naive CD4+ T cell
activation. Because DC are efficient at Ag processing and could potentially present self Ags …