Molecular mechanisms of anticancer effect of rutin

A Imani, N Maleki, S Bohlouli… - Phytotherapy …, 2021 - Wiley Online Library
Because of the extensive biological functions of natural substances such as bioflavonoids,
and their high safety and low costs, they could have high priority application in the health …

Anti-cancer effect and underlying mechanism (s) of kaempferol, a phytoestrogen, on the regulation of apoptosis in diverse cancer cell models

SH Kim, KC Choi - Toxicological research, 2013 - Springer
Phytoestrogens exist in edible compounds commonly found in fruits or plants. For long
times, phytoestrogens have been used for therapeutic treatments against human diseases …

Treatment with kaempferol suppresses breast cancer cell growth caused by estrogen and triclosan in cellular and xenograft breast cancer models

SH Kim, KA Hwang, KC Choi - The Journal of nutritional biochemistry, 2016 - Elsevier
As a phytoestrogen, kaempferol (Kaem) is one of bioflavonoids, which are found in a variety
of vegetables including broccoli, tea and tomato. In this study, the antiproliferative effects of …

The prodomain of caspase-3 regulates its own removal and caspase activation

KG Ponder, LH Boise - Cell death discovery, 2019 - nature.com
Caspase-3 is a cysteine–aspartic acid protease that cleaves cellular targets and executes
cell death. Our current understanding is caspase-3 is activated by the cleavage of the …

Rutin mediated targeting of signaling machinery in cancer cells

AA Perk, I Shatynska-Mytsyk, YC Gerçek… - Cancer cell …, 2014 - Springer
Progress in our understanding of molecular oncology has started to shed light on
dysregulation of spatio-temporally controlled signaling pathways, inactivation of tumor …

Beneficial effects of quercetin on vincristine‐induced liver injury in rats: Modulating the levels of Nrf2/HO‐1, NF‐kB/STAT3, and SIRT1/PGC‐1α

S Çomaklı, S Özdemir, S Küçükler… - Journal of Biochemical …, 2023 - Wiley Online Library
Our experimental objective was to investigate the hepatotoxic effect of vincristine (VCR)
administration in rats and determined whether combined therapy with Quercetin (Quer) …

[HTML][HTML] Phytochemicals, antioxidant and anti-proliferative activities of Myrtus communis L. genotypes from Tunisia

I Yangui, F Younsi, W Ghali, M Boussaid… - South African Journal of …, 2021 - Elsevier
Myrtle (Myrtus communis L.) has long been regarded as a medicinal and aromatic plant. The
analysis of phenolic and terpenic compounds contained in the leaf extracts of three Myrtle …

Health and cellular impacts of air pollutants: from cytoprotection to cytotoxicity

K Andreau, M Leroux… - Biochemistry research …, 2012 - Wiley Online Library
Air pollution as one of the ravages of our modern societies is primarily linked to urban
centers, industrial activities, or road traffic. These atmospheric pollutants have been …

Isovitexin (IV) induces apoptosis and autophagy in liver cancer cells through endoplasmic reticulum stress

SX Lv, X Qiao - Biochemical and biophysical research communications, 2018 - Elsevier
Liver cancer is a leading cause of cancer death worldwide, and novel chemotherapeutic
drugs to suppress liver cancer are urgently required. Isovitexin (IV), a glycosylflavonoid, is …

Anticancer and antibacterial activity studies of gold (I)-alkynyl chromones

P Hikisz, Ł Szczupak, A Koceva-Chyła, A Guśpiel… - Molecules, 2015 - mdpi.com
Three gold (I) complexes of alkynyl chromones were synthesized and characterized. The
single-crystal X-ray structure analysis of a dinuclear compound and of a flavone derivative …