Pyruvate is irreversibly decarboxylated to acetyl coenzyme A by mitochondrial pyruvate
dehydrogenase complex (PDC). Decarboxylation of pyruvate is considered a crucial step in …

Cancer chemoprevention is the most effective approach to control cancer in the population.
Despite significant progress, chemoprevention has not been widely adopted because …

Photoredox catalysis (PRC) is a cutting-edge frontier for single electron-transfer (SET)
reactions, enabling the generation of reactive intermediates for both oxidative and reductive …

An electrochemical oxydihalogenation of alkynes has been developed for the first time.
Using this sustainable protocol, a variety of α, α-dihaloketones can be prepared with readily …

The current standard-of-care for metastatic colorectal cancer (mCRC) includes
chemotherapy and anti-angiogenic or anti-epidermal growth factor receptor (EGFR) …

Calothrixin A (CAA) is a dual Topo I and II inhibitor but exhibits poor antiproliferative
activities and water solubility. Herein, a library of novel CAA analogues was synthesized …

Proliferating cancer cells are characterized by the Warburg effect, a metabolic alteration in
which ATP is generated from cytoplasmic glycolysis instead of oxidative phosphorylation …

Synthetic photoelectrochemistry shows significant advantages in handling of reactive
intermediates via a sustainable way and has developed to be the frontier of single electron …

Phenylbutyric acid (PBA) has been reported as a dual inhibitor of pyruvate dehydrogenase
kinases (PDKs) and histone deacetylases (HDACs), exhibiting anticancer effects. However …

Cancer is one of the most important problems that endanger human health. The number of
cancer patients is increasing rapidly worldwide. Compared with normal cells, cancer cells …