MicroRNAs (miRNAs) constitute a large class of short RNAs (eg, 20–24 nucleotides in
length), whose main function is to posttranscriptionally regulate the expression of protein …

Aliment Pharmacol Ther 31, 461–476 Summary Background Hepatocellular carcinoma is
the leading cause of death in cirrhosis. A majority of patients present at an advanced stage …

Tumor-associated macrophages (TAM) represent key regulators of the complex interplay
between cancer and the immune microenvironment. Matricellular protein SPON2 is …

BACKGROUND & AIMS: Sorafenib plus metronomic tegafur/uracil therapy can induce tumor
stabilization in advanced hepatocellular carcinoma (HCC) patients. This study evaluated the …

Hepatocellular carcinoma (HCC) ranks as the third most common cause of death from
cancer worldwide. Although major risk factors for the development of HCC have been …

Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide.
The major etiologies and risk factors for development of HCC are well defined and some …

Liver and kidney cancers are notorious for drug resistance. Due to the complexity,
redundancy and interpatient heterogeneity of resistance mechanisms, most efforts targeting …

Hepatocellular carcinoma (HCC) is a highly lethal malignancy mostly because of de novo
and acquired resistance to conventional chemotherapy. Constitutive activation of Akt and …

Platycodin D (PD), a major saponin derived and isolated from the roots of Platycodon
grandiflorum, exerts potent growth inhibition and strong cytotoxicity against various cancer …

The miR‑222 cluster has been demonstrated to function as oncomiR in human
hepatocellular carcinoma (HCC). miR‑222 confers chemotherapy drug resistance in various …