The T cell receptor (TCR) complex is a naturally occurring antigen sensor that detects,
amplifies and coordinates cellular immune responses to epitopes derived from cell surface …

The cellular stress and immunity cycle is a cornerstone of organismal homeostasis. Stress
activates intracellular and intercellular communications within a tissue or organ to initiate …

Glioblastoma (GBM) is one of the most lethal central nervous systems (CNS) tumours in
adults. As supplements to standard of care (SOC), various immunotherapies improve the …

High‐performance theranostic systems are of paramount importance for achieving precise
image‐guided cancer immunotherapy. Here, a novel nanoplatform is presented that …

The aim of personalized cancer vaccines is to elicit potent and tumor-specific immune
responses against neoantigens specific to each patient and to establish durable immunity …

In this commentary, we advance the notion that mutant KRAS (mKRAS) is an ideal tumor
neoantigen that is amenable for targeting by the adaptive immune system. Recent progress …

We have applied our advanced computational and experimental methodologies to
investigate the complex structure and binding mechanism of a modified Wilms' Tumor 1 …

Inducing immunogenic cell death (ICD) during photothermal therapy (PTT) has the potential
to effectively trigger photothermal immunotherapy (PTI). However, ICD induced by PTT …

Cancer immunotherapies based on cytotoxic CD8+ T lymphocytes (CTLs) are highly
promising for cancer treatment. The specific interaction between T-cell receptors and …

Insufficient antigen self-presentation of tumor cells and ineffective antigen cross-
presentation by dendritic cells (DCs) contribute to diminished immune recognition and …