When the non-coding repeat expansion in the C9ORF72 gene was discovered to be the
most frequent cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis …

Amyotrophic lateral sclerosis (ALS) is a fatal, multigenic, multifactorial, and non-cell
autonomous neurodegenerative disease characterized by upper and lower motor neuron …

The hexanucleotide repeat expansion (HRE) in the C9ORF72 gene is the main cause of two
tightly linked neurodegenerative diseases, amyotrophic lateral sclerosis (ALS) and …

Synaptic loss is a pathological feature of all neurodegenerative diseases including
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). ALS is a disease of …

Amyotrophic lateral sclerosis (ALS) is a severe adult motor neuron disease that causes
progressive neuromuscular atrophy, muscle wasting, weakness, and depressive-like …

Drug development is hampered by poor target selection. Phenotypic screens using neurons
differentiated from patient stem cells offer the possibility to validate known and discover …

The GGGGCC intronic repeat expansion within C9ORF72 is the most common genetic
cause of ALS and FTD. This mutation results in toxic gain of function through accumulation …

In order to dissect amyotrophic lateral sclerosis (ALS), a multigenic, multifactorial, and
progressive neurodegenerative disease with heterogeneous clinical presentations …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that affects the first
and second motoneurons (MNs), associated with muscle weakness, paralysis and finally …

Amyotrophic lateral sclerosis (ALS) is a paralytic disease that damages the brain and spinal
cord motor neurons. Several clinical and preclinical studies have found that methylmercury …