[HTML][HTML] Serum galectins as potential biomarkers of inflammatory bowel diseases

TB Yu, S Dodd, LG Yu, S Subramanian - PLoS One, 2020 - journals.plos.org
The inflammatory bowel diseases (IBD), which include mainly Crohn's disease (CD) and
ulcerative colitis (UC), are common chronic inflammatory conditions of the digestive system …

[HTML][HTML] Roles of galectin‑3 in the tumor microenvironment and tumor metabolism

Y Guo, R Shen, L Yu, X Zheng, R Cui… - Oncology …, 2020 - spandidos-publications.com
Galectin‑3 is expressed in various tissues and plays an important role in the tumor
microenvironment (TME). Galectin‑3 has been found to be overexpressed in a variety of …

[HTML][HTML] Endoglin protein interactome profiling identifies TRIM21 and Galectin-3 as new binding partners

E Gallardo-Vara, L Ruiz-Llorente, J Casado-Vela… - Cells, 2019 - mdpi.com
Endoglin is a 180-kDa glycoprotein receptor primarily expressed by the vascular
endothelium and involved in cardiovascular disease and cancer. Heterozygous mutations in …

[HTML][HTML] Galectin-3 is a natural binding ligand of MCAM (CD146, MUC18) in melanoma cells and their interaction promotes melanoma progression

Y Pang, E Maxwell, P Sindrewicz-Goral, A Shapanis… - Biomolecules, 2022 - mdpi.com
Melanoma cell adhesion molecule (MCAM, CD146, MUC18) is a heavily glycosylated
transmembrane protein and a marker of melanoma metastasis. It is expressed in advanced …

[HTML][HTML] Glycan-Lectin Interactions as Novel Immunosuppression Drivers in Glioblastoma

A Pace, F Scirocchi, C Napoletano, IG Zizzari… - International Journal of …, 2022 - mdpi.com
Despite diagnostic and therapeutic improvements, glioblastoma (GB) remains one of the
most threatening brain tumor in adults, underlining the urgent need of new therapeutic …

[HTML][HTML] Galectin functions in cancer-associated inflammation and thrombosis

L Kruk, A Braun, E Cosset, T Gudermann… - Frontiers in …, 2023 - frontiersin.org
Galectins are carbohydrate-binding proteins that regulate many cellular functions including
proliferation, adhesion, migration, and phagocytosis. Increasing experimental and clinical …

[HTML][HTML] Unraveling how tumor-derived galectins contribute to anti-cancer immunity failure

DJ Laderach, D Compagno - Cancers, 2021 - mdpi.com
Simple Summary This review compiles our current knowledge of one of the main pathways
activated by tumors to escape immune attack. Indeed, it integrates the current understanding …

[HTML][HTML] Galectin-9 as a Potential Modulator of Lymphocyte Adhesion to Endothelium via Binding to Blood Group H Glycan

EM Rapoport, IM Ryzhov, EV Slivka, EY Korchagina… - Biomolecules, 2023 - mdpi.com
The recruitment of leukocytes from blood is one of the most important cellular processes in
response to tissue damage and inflammation. This multi-step process includes rolling …

[HTML][HTML] C1GalT1 expression reciprocally controls tumour cell-cell and tumour-macrophage interactions mediated by galectin-3 and MGL with double impact on …

Y Wan, K Adair, A Herrmann, X Shan, L Xia… - Cell death & …, 2023 - nature.com
Although most cell membrane proteins are modified by glycosylation, our understanding of
the role and actions of protein glycosylation is still very limited. β1, 3galactosyltransferase …

CD146 as a promising therapeutic target for retinal and choroidal neovascularization diseases

B Xue, P Wang, W Yu, J Feng, J Li, R Zhao… - Science China Life …, 2022 - Springer
Blood vessel dysfunction causes several retinal diseases, including diabetic retinopathy,
familial exudative vitreoretinopathy, macular degeneration and choroidal neovascularization …