Sotatercept for Pulmonary Arterial Hypertension in the Inpatient Setting

H Torbic, AR Tonelli - Journal of Cardiovascular …, 2024 - journals.sagepub.com
Patients with pulmonary arterial hypertension (PAH) who are admitted to the hospital pose a
challenge to the multidisciplinary healthcare team due to the complexity of the …

activin signalling inhibitors for the treatment of pulmonary arterial hypertension

M Humbert - European Respiratory Journal, 2023 - Eur Respiratory Soc
Extract Pulmonary vascular remodelling and dysfunction are hallmarks of pulmonary arterial
hypertension (PAH), a rare and severe form of pre-capillary pulmonary hypertension …

Seralutinib in adults with pulmonary arterial hypertension (TORREY): a randomised, double-blind, placebo-controlled phase 2 trial

RP Frantz, VV McLaughlin, S Sahay… - The Lancet …, 2024 - thelancet.com
Background Morbidity and mortality in pulmonary arterial hypertension (PAH) remain high.
Activation of platelet-derived growth factor receptor, colony stimulating factor 1 receptor, and …

Risk stratification refinements with inclusion of haemodynamic variables at follow-up in patients with pulmonary arterial hypertension

A Boucly, A Beurnier, S Turquier… - European …, 2024 - Eur Respiratory Soc
Background and Aims Haemodynamic variables are prognostic factors in pulmonary arterial
hypertension (PAH). However, right heart catheterization (RHC) is not systematically …

Primum non nocere, secundum cavere, tertium sanare: lessons on the management of pulmonary hypertension associated with COPD

G Kovacs, M Humbert - European Respiratory Journal, 2024 - Eur Respiratory Soc
Extract One of the central elements of the hippocratic oath is to abstain from doing harm–
primum non nocere. According to some sources, this should be followed by being cautious …

SPECTRA Phase 2b Study: Impact of Sotatercept on Exercise Tolerance and Right Ventricular Function in Pulmonary Arterial Hypertension

AB Waxman, DM Systrom, S Manimaran… - Circulation: Heart …, 2024 - Am Heart Assoc
BACKGROUND: This study aims to assess the impact of sotatercept on exercise tolerance,
exercise capacity, and right ventricular function in pulmonary arterial hypertension …

ERJ 2024: your journal, my journal, our journal

DD Sin, JD Chalmers - European Respiratory Journal, 2024 - Eur Respiratory Soc
Extract Our 5-year mission at the European Respiratory Journal (ERJ) is to be the best
journal in respiratory medicine, to publish outstanding science and to be the “go-to” …

Prognostic role of haemodynamics at follow-up in patients with pulmonary arterial hypertension: a challenge to current ESC/ERS risk tools

F Dardi, D Guarino, A Ballerini, R Bertozzi… - ERJ Open …, 2024 - Eur Respiratory Soc
Background Hemodynamic variables like right atrial pressure (RAP), cardiac index (CI),
stroke volume index (SVI) and mixed venous oxygen saturation (SvO2) predict survival in …

Reducing the pressure in pulmonary arterial hypertension: sotatercept, haemodynamics and the right ventricle

LC Price, C McCabe… - European Respiratory …, 2023 - Eur Respiratory Soc
Extract Pulmonary arterial hypertension (PAH) is a severe progressive disease
characterised by obliterative vascular remodelling and increased resistance in small and …

ERS International Congress 2023: highlights from the Pulmonary Vascular Diseases Assembly

S Cullivan, A Boucly, M Jevnikar… - ERJ Open …, 2024 - Eur Respiratory Soc
Pulmonary vascular diseases such as pulmonary embolism and pulmonary hypertension
are important and frequently under-recognised conditions. This article provides an overview …