Metabolomics: small molecules that matter more

BC Muthubharathi, T Gowripriya, K Balamurugan - Molecular omics, 2021 - pubs.rsc.org
Metabolomics, an analytical study with high-throughput profiling, helps to understand
interactions within a biological system. Small molecules, called metabolites or metabolomes …

Promises and pitfalls of untargeted metabolomics

I Gertsman, BA Barshop - Journal of inherited metabolic disease, 2018 - Springer
Metabolomics is one of the newer omics fields, and has enabled researchers to complement
genomic and protein level analysis of disease with both semi-quantitative and quantitative …

Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites

WR Wikoff, AT Anfora, J Liu… - Proceedings of the …, 2009 - National Acad Sciences
Although it has long been recognized that the enteric community of bacteria that inhabit the
human distal intestinal track broadly impacts human health, the biochemical details that …

Global metabolic profiling procedures for urine using UPLC–MS

EJ Want, ID Wilson, H Gika, G Theodoridis, RS Plumb… - Nature protocols, 2010 - nature.com
The production of'global'metabolite profiles involves measuring low molecular-weight
metabolites (< 1 kDa) in complex biofluids/tissues to study perturbations in response to …

Integrated, nontargeted ultrahigh performance liquid chromatography/electrospray ionization tandem mass spectrometry platform for the identification and relative …

AM Evans, CD DeHaven, T Barrett, M Mitchell… - Analytical …, 2009 - ACS Publications
To address the challenges associated with metabolomics analyses, such as identification of
chemical structures and elimination of experimental artifacts, we developed a platform that …

[HTML][HTML] Applications of machine learning in metabolomics: Disease modeling and classification

A Galal, M Talal, A Moustafa - Frontiers in genetics, 2022 - frontiersin.org
Metabolomics research has recently gained popularity because it enables the study of
biological traits at the biochemical level and, as a result, can directly reveal what occurs in a …

Current trends and challenges in sample preparation for global metabolomics using liquid chromatography–mass spectrometry

D Vuckovic - Analytical and bioanalytical chemistry, 2012 - Springer
The choice of sample-preparation method is extremely important in metabolomic studies
because it affects both the observed metabolite content and biological interpretation of the …

[HTML][HTML] Defining the metabolome: size, flux, and regulation

N Zamboni, A Saghatelian, GJ Patti - Molecular cell, 2015 - cell.com
Renewed interest in metabolic research over the last two decades has inspired an explosion
of technological developments for studying metabolism. At the forefront of methodological …

HILIC‐MS for metabolomics: An attractive and complementary approach to RPLC‐MS

DQ Tang, L Zou, XX Yin, CN Ong - Mass spectrometry reviews, 2016 - Wiley Online Library
Hydrophilic interaction chromatography (HILIC) is an emerging separation mode of liquid
chromatography (LC). Using highly hydrophilic stationary phases capable of retaining …

Clinical applications of metabolomics in oncology: a review

JL Spratlin, NJ Serkova, SG Eckhardt - Clinical cancer research, 2009 - AACR
Metabolomics, an omic science in systems biology, is the global quantitative assessment of
endogenous metabolites within a biological system. Either individually or grouped as a …